Qi-Cheng Qiao

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The medial entorhinal cortex (MEC) plays a crucial role in spatial learning and memory. Whereas the MEC receives a dense histaminergic innervation from the tuberomamillary nucleus of the hypothalamus, the functions of histamine in this brain region remain unclear. Here, we show that histamine acts via H1Rs to directly depolarize the principal neurons in the(More)
The neuropeptides orexin-A and orexin-B are produced by one group of neurons located in the lateral hypothalamic/perifornical area. However, the orexins are widely released in entire brain including various central motor control structures. Especially, the loss of orexins has been demonstrated to associate with several motor deficits. Here, we first(More)
Orexin neurons in the lateral hypothalamus (LH) play an important role in arousal, guaranteeing the execution of medial prefrontal cortex (mPFC)-related higher cognitive functions. The mPFC is anatomically and functionally a rostro-caudal hierarchy. Little is known about the innervation pattern, especially in the rostro-caudal model, from the(More)
The central noradrenergic system participates in diverse nervous functions. Nevertheless, our knowledge of the action of adrenoceptors in motor regulation is still lacking. Intriguingly, reticulospinal neurons in the caudal pontine reticular nucleus (PnC) receive fairly dense noradrenergic innervation and play an important role in motor control. Here, after(More)
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