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INTRODUCTION AND AIMS Mucin 1 (MUC1) is a transmembrane glycoprotein that is overexpressed in many tumor types, including breast, pancreatic, and ovarian cancer. The aim of this study was to create a construct containing sodium-iodide symporter (NIS) under the control of the 0.8-kb MUC1 promoter to infect pancreatic cancer cells both in vitro and in vivo,(More)
On-line capillary isoelectric focusing (CIEF)-electrospray ionization mass spectrometry (ESIMS) as a two-dimensional separation system is employed for high-resolution analysis of hemoglobin variants A, C, S, and F. The effects of moving ionic boundary inside the CIEF capillary and MS scan rate on the separation resolution and mass detection of hemoglobin(More)
On-line capillary isoelectric focusing (CIEF)-electrospray ionization mass spectrometry (ESIMS) as a two-dimensional separation system is employed for high-resolution analysis of bovine serum apotransferrin glycoforms. On the basis of their differences in isoelectric point (pI), the di-, tri-, and tetrasialotransferrins are separated and resolved in CIEF.(More)
Objective: To investigate the clinical effect of plasma exchange (PE) versus double plasma molecular adsorption system combined with PE (DPMAS+PE) in the treatment of toxic hepatic failure. Methods: A total of 67 patients with toxic hepatic failure who were admitted during the same period of time were divided into PE group, DPMAS+ PE group, and control(More)
The electroosmotic mobilization of focused protein zones in a fused-silica capillary is investigated using a mixture of model proteins, including alpha-chymotrypsinogen A (bovine pancreas), myoglobin (horse heart) and carbonic anhydrase II (bovine erythrocytes). The presence of carrier ampholytes in the entire capillary and the adsorption of carrier(More)
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