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Helicobacter pylori-Induced Th17 Responses Modulate Th1 Cell Responses, Benefit Bacterial Growth, and Contribute to Pathology in Mice
The results together suggest that H. pylori infection induces a mixed Th17/Th1 cell response and the Th 17/IL-17 pathway modulates Th1 cell responses and contributes to pathology. Expand
Identification of MyD88 as a novel target of miR‐155, involved in negative regulation of Helicobacter pylori‐induced inflammation
It is demonstrated that miR‐155 can negatively regulate inflammation by targeting a key adaptor molecule MyD88 in inflammatory pathways by exploiting its role as a central regulator of the immune system. Expand
Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response.
- B. Xiao, Zhen Liu, +10 authors Q. Zou
- Biology, Medicine
- The Journal of infectious diseases
- 1 September 2009
This study provides the first description of increased expression of miR-155 in H. pylori infection, and it is suggested that this molecule may function as novel negative regulator that help to fine-tune the inflammation response of H. Pylori. Expand
Up-regulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cells.
H. pylori-induced miR-146a plays a potential role in a negative feedback loop to modulate the inflammation by targeting IRAK1 and TRAF6. Expand
Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway
The results illuminate a novel mechanism of PD-L1 expression on tumour-activated neutrophils in GC, and provide functional evidence for these novel GM-CSF-PD-L 1 pathways to prevent, and to treat this immune tolerance feature of GC. Expand
CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer.
The percentage of Tc17 cells increased with tumor progression and was associated with overall survival time, and these cells promote chemotaxis of MDSCs, which might promote tumor progression. Expand
Progress and Prospects on Vaccine Development against SARS-CoV-2
This review mainly focused on the progress and prospects on field of vaccine development against SARS-CoV-2, with some that have entered efficacy evaluation in animals and initial clinical trials. Expand
Attenuated CagA Oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon*
- Masato Suzuki, Kotaro Kiga, +12 authors C. Sasakawa
- Biology, Medicine
- The Journal of Biological Chemistry
- 8 July 2011
It is suggested that Amerindian cagA is of relatively low virulence, that this may have been selected in ancestral strains during infection of the people who migrated from Asia into the Americas many thousands of years ago, and that such attenuated CagA proteins could be useful therapeutically. Expand
Plasma microRNAs, miR-223, miR-21 and miR-218, as Novel Potential Biomarkers for Gastric Cancer Detection
Low plasma levels of four miRNAs closely associated with the tumorigenesis or metastasis of GC can serve as novel potential biomarkers for GC detection, and the areas under the receiver operating characteristic (ROC) curves of these mi RNAs were analyzed. Expand
Compromised autophagy by MIR30B benefits the intracellular survival of Helicobacter pylori
It is shown that MIR30B is upregulated during H. pylori infection of an AGS cell line and human gastric tissues and it is demonstrated that M IR30B directly targets ATG12 and BECN1, which are important proteins involved in autophagy. Expand