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Rapid development of broadly influenza neutralizing antibodies through redundant mutations
The neutralizing antibody response to influenza virus is dominated by antibodies that bind to the globular head of haemagglutinin, which undergoes a continuous antigenic drift, necessitating theExpand
Profile of IgG and IgM antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Abstract We profiled the serological responses to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein and spike (S) glycoprotein. The majority of the patientsExpand
Is a distinctive single Tg a reliable indicator for the homogeneity of amorphous solid dispersion?
For an amorphous drug-polymer solid dispersion, a distinctive single T(g) intermediate of the two T(g) values of the two components has been widely considered as an indication of the mixingExpand
MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN
Intrahepatic cholangiocarcinoma (ICC) constitutes the second-most common primary hepatic malignancy. MicroRNAs (miRNAs) play important roles in the pathogenesis of ICC. However, the clinicalExpand
Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through
IntroductionAcquired tamoxifen resistance remains the major obstacle to breast cancer endocrine therapy. β1-integrin was identified as one of the target genes of G protein-coupled estrogen receptorExpand
Lactoferrin potently inhibits osteoblast apoptosis, via an LRP1-independent pathway
Lactoferrin induces osteoblast proliferation in vitro and is anabolic to bone in vivo. We recently reported that the low-density lipoprotein-receptor-related protein 1 (LRP1), a multifunctionalExpand
Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma
Purpose. Yes-associated protein (YAP) and PDZ-binding motif (TAZ) are two important effectors of Hippo pathway controlling the balance of organ size and carcinogenesis. Amphiregulin (AREG) is aExpand
Serum SALL4 Is a Novel Prognosis Biomarker with Tumor Recurrence and Poor Survival of Patients in Hepatocellular Carcinoma
Aim. Sal-like protein 4 (SALL4), is reexpressed in tissues of a subgroup of HCC associated with poor prognosis. Reports of SALL4 serological levels linked to HCC patients are meager and unclear inExpand
Interactions between urban heat islands and heat waves
Author(s): Zhao, L; Oppenheimer, M; Zhu, Q; Baldwin, JW; Ebi, KL; Bou-Zeid, E; Guan, K; Liu, X | Abstract: © 2018 The Author(s). Published by IOP Publishing Ltd. Heat waves (HWs) are among the mostExpand
Triangulation of Well-Defined Points as a Constraint for Reliable Image Matching
This study demonstrates the utilization of the well-defined points to improve the reliability and accuracy of image matching. The basic principle is: (a) to triangulate a few well-defined pointsExpand