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The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ
Interferon-γ (IFN-γ) has a critical role in immune responses to intracellular bacterial infection. MicroRNAs (miRNAs) are important in the regulation of innate and adaptive immunity. However, whether… Expand
School-milk intervention trial enhances growth and bone mineral accretion in Chinese girls aged 10-12 years in Beijing.
A 2-year milk intervention trial was carried out with 757 girls, aged 10 years, from nine primary schools in Beijing (April 1999 - March 2001). Schools were randomised into three groups: group 1, 238… Expand
Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells
Rejuvenation of telomeres with various lengths has been found in induced pluripotent stem cells (iPSCs). Mechanisms of telomere length regulation during induction and proliferation of iPSCs remain… Expand
Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases
Maspin (SERPINB5), a serine proteinase inhibitor, was first identified as a potential tumor suppressor on the basis of its differential expression between normal mammary epithelial cells and human… Expand
Inulin-type fructan improves diabetic phenotype and gut microbiota profiles in rats
Background & Aims Accumulating research has addressed the linkage between the changes to gut microbiota structure and type 2 diabetes (T2D). Inulin is one type of soluble dietary fiber that can… Expand
Imbalance of Fecal Microbiota at Newly Diagnosed Type 1 Diabetes in Chinese Children
Background:Recent studies have indicated that an imbalance of gut microbiota is associated with the development of type 1 diabetes mellitus (T1DM) and there is no literature regarding it in Chinese… Expand
Trends of imported malaria in China 2010–2014: analysis of surveillance data
BackgroundTo describe the epidemiologic profile and trends of imported malaria, and to identify the populations at risk of malaria in China during 2010–2014.MethodsThis is a descriptive analysis of… Expand
Autophagy activation: a novel mechanism of atorvastatin to protect mesenchymal stem cells from hypoxia and serum deprivation via AMP-activated protein kinase/mammalian target of rapamycin pathway.
Autophagy is a complex "self-eating" process and could be utilized for cell survival under stresses. Statins, which could reduce apoptosis in mesenchymal stem cells (MSCs) during both ischemia and… Expand
The Placental Microbiome Varies in Association with Low Birth Weight in Full-Term Neonates
Substantial evidence indicated that low birth weight was an independent risk factor for obesity, impaired glucose regulation, and diabetes later in life. However, investigations into the association… Expand
Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype.
- Huie Jing, Q. Zhang, +16 authors H. Su
- Biology, Medicine
- The Journal of allergy and clinical immunology
- 1 June 2014
BACKGROUND Autosomal recessive loss-of-function mutations in dedicator of cytokinesis 8 (DOCK8) cause a combined immunodeficiency characterized by atopy, recurrent infections, and cancer… Expand