• Publications
  • Influence
Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel.
A targeted intracellular delivery system of paclitaxel (PTX) was successfully developed based on redox-sensitive hyaluronic acid-deoxycholic acid (HA-ss-DOCA) conjugates. The conjugatesExpand
  • 311
  • 14
Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals.
  • X. Ying, H. Wen, +11 authors Q. Zhang
  • Medicine
  • Journal of controlled release : official journal…
  • 25 January 2010
Chemotherapy for brain glioma has been of limited value due to the inability of transport of drug across the blood-brain barrier (BBB) and poor penetration of drug into the tumor. For overcomingExpand
  • 320
  • 9
Diverse Applications of Nanomedicine
The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude ofExpand
  • 405
  • 9
  • PDF
Preparation and antitumor study of camptothecin nanocrystals.
Camptothecin (CPT) is a potent, broad spectrum antitumor agent that inhibits the activity of DNA topoisomerase I. Due to its poor solubility and stability and consequent delivery challenges, itsExpand
  • 108
  • 8
Controlled delivery of recombinant hirudin based on thermo-sensitive Pluronic F127 hydrogel for subcutaneous administration: In vitro and in vivo characterization.
Here we investigated thermo-sensitive Pluronic(R) F127 (PF127) hydrogel for the controlled release of peptide and protein drugs after subcutaneous injection, using an antithrombotic polypeptide,Expand
  • 131
  • 7
The transport mechanisms of polymer nanoparticles in Caco-2 epithelial cells.
As the primary physiological barrier, intestinal epithelial cells regulate the transportation of oral therapeutic agents including nanomedicines which significantly improves the bioavailability ofExpand
  • 135
  • 7
A novel mixed micelle gel with thermo-sensitive property for the local delivery of docetaxel.
In the present study, we incorporated docetaxel (DTX) into an injectable thermo-sensitive mixed micelle gel (MMG). It was found that the mixed micelle composed of Pluronic F127 (PF127) and Tween 80Expand
  • 108
  • 7
Bioavailability and pharmacokinetics of cyclosporine A-loaded pH-sensitive nanoparticles for oral administration.
The pH-sensitive cyclosporine A (CyA) nanoparticles were prepared by the solvent displacement method with enteric dissolved polymer of hydroxypropyl methylcellulose phthalate (HPMCP; including HP50Expand
  • 66
  • 7
Targeted delivery of RGD-modified liposomes encapsulating both combretastatin A-4 and doxorubicin for tumor therapy: in vitro and in vivo studies.
Arg-Gly-Asp (RGD) modified doxorubicin-loaded liposomes could improve anticancer effect, and vascular disrupting agents (VDAs) could induce a rapid and selective shutdown of the blood vessels ofExpand
  • 110
  • 6
Phase II Trial of Neoadjuvant/adjuvant Imatinib Mesylate for Advanced Primary and Metastatic/recurrent Operable Gastrointestinal Stromal Tumors: Long-term Follow-up Results of Radiation Therapy
BackgroundImatinib inhibits the KIT and PDGFR tyrosine kinases, resulting in its notable antitumor activity in gastrointestinal stromal tumor (GIST). We previously reported the early results of aExpand
  • 140
  • 6