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Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder
TLDR
In a paternal mouse model given a high-fat diet, a subset of sperm transfer RNA–derived small RNAs (tsRNAs), mainly from 5′ transfer RNA halves and ranging in size from 30 to 34 nucleotides, exhibited changes in expression profiles and RNA modifications.
A local mechanism mediates NAD-dependent protection of axon degeneration
TLDR
It is demonstrated that NAD levels decrease in degenerating axons and that preventing this axonal NAD decline efficiently protects axons from degeneration, suggesting a novel molecular pathway for axon degeneration.
Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1‐dependent adenosine monophosphate–activated kinase pathway
TLDR
The role of Nampt in brain and stroke remains to be investigated and Nicotinamide phosphoribosyltransferase is implicated in cell fate decisions.
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs
TLDR
It is reported that tRNA methyltransferase Dnmt2 is required for sperm small-non-coding-RNA-mediated transmission of paternal metabolic disorders to the offspring and that DnMT2-mediated m5C contributes to the secondary structure and biological properties of sncRNAs, implicating sperm RNA modifications as an additional layer of paternal hereditary information.
Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia
TLDR
The results demonstrate that Nampt promotes neuronal survival through inducing autophagy via regulating TSC2-mTOR-S6K1 signaling pathway in a SIRT1-dependent manner during cerebral ischemia.
Alcohol‐induced oxidative stress and cell responses
TLDR
Recent literature on alcohol‐induced ROS production, oxidative stress, signal transduction, and cellular responses is reviewed, and the implication of these processes in alcohol‐related diseases is discussed.
Cytoplasm‐localized SIRT1 enhances apoptosis
TLDR
SIRT1 is able to localize in cy toplasm, and cytoplasm‐localized SIRT1 enhances apoptosis, which is associated with apoptosis and led to increased sensitivity to apoptosis.
CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1
TLDR
It is shown that CLOCK and brain and muscle ARNT‐like protein 1 (BMAL1), two core circadian transcription factors, are correlated with hepatic insulin sensitivity and a potential application of resveratrol for combating circadian misalignment‐induced metabolic disorders is provided.
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