• Publications
  • Influence
X-RAY STRUCTURE OF GELATINASE A CATALYTIC DOMAIN COMPLEXED WITH A HYDROXAMATE INHIBITOR
Gelatinase A is a key enzyme in the family of matrix metalloproteinases (matrixins) that are involved in the degradation of the extracellular matrix. As this process is an integral part of tumourExpand
  • 58
  • 4
Calcium stoichiometry determination for calcium binding proteins by electrospray ionization mass spectrometry.
Electrospray ionization mass spectrometry was used for the determination of calcium-binding stoichiometry for calcium-binding proteins. Bovine calmodulin, bovine alpha-lactalbumin, and rabbitExpand
  • 92
  • 2
p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase.
  • Q. Ye, J. Liu, C. Walsh
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 December 1990
The Escherichia coli pabA and pabB genes have been overexpressed separately and in tandem. Using purified PabB, we have confirmed the recent suggestion that PabB needs an additional protein, enzymeExpand
  • 64
  • 2
Nitrogen-containing dihydro-β-agarofuran derivatives from Tripterygium wilfordii.
Thunder god vine, the dried roots of Tripterygium wilfordii, is a widely used traditional Chinese medicine. More than 200 bioactive complex natural products have been isolated from this herb.Expand
  • 24
  • 2
A novel alkaloid from Mitrephora maingayi
A novel alkaloid, maingayinine, together with dicentrinone, dicentrinene, L-2-O-methyl-chiro-inositol, allantoin, glaucine, N-phenyl-2-naphthylamine, terephthalic acid and ayanin, was isolated fromExpand
  • 13
  • 1
X‐ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: Implications for inhibitor selectivity
Effective inhibitors of matrix metalloproteinases (MMPs), a family of connective tissue‐degrading enzymes, could be useful for the treatment of diseases such as cancer, multiple sclerosis, andExpand
  • 48
Structural analysis of metalloform-selective inhibition of methionine aminopeptidase.
One of the challenges in the development of methionine aminopeptidase (MetAP) inhibitors as antibacterial and anticancer agents is to define the metal ion actually used by MetAP in vivo and toExpand
  • 15
  • PDF
Dihydroagarofuran derivatives from the dried roots of Tripterygium wilfordii.
Five new sesquiterpene derivatives, including dihydroagarofuran pyridine macrolides 1-4 and dihydroagarofuran ester 18, and 13 known dihydroagarofuran derivatives were isolated from the aqueous EtOHExpand
  • 25
Effect of redox potential regulation on succinic acid production by Actinobacillus succinogenes
The effects of redox potential used as a control parameter on the process of succinic acid production in batch cultures of Actinobacillus succinogenes NJ113 have been investigated. In batchExpand
  • 43