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The quest for modernisation of traditional Chinese medicine
Traditional Chinese medicine (TCM) is an integral part of mainstream medicine in China. Due to its worldwide use, potential impact on healthcare and opportunities for new drug development, TCM isExpand
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Transcriptional Induction of Mitogen-activated Protein Kinase Phosphatase 1 by Retinoids
All-trans-retinoic acid (t-RA) inhibits hydrogen peroxide (H2O2)-induced apoptosis by inhibiting the c-Jun N-terminal kinase (JNK)-activator protein 1 (AP-1) pathway. In this report, we examined theExpand
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Cellular defense against H2O2-induced apoptosis via MAP kinase-MKP-1 pathway.
Mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) is an oxidative stress-inducible gene. In this study, we investigated signaling pathways involved in oxidative stress-induced MKP-1Expand
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In vitro anti-fibrotic activities of herbal compounds and herbs.
  • Qin Hu, M. Noor, +6 authors Q. Xu
  • Biology, Medicine
  • Nephrology, dialysis, transplantation : official…
  • 1 October 2009
BACKGROUND We recently developed high-throughput assays of inflammation-independent anti-fibrotic activities based on TGF-beta1-induced total collagen accumulation and nodule formation in normal ratExpand
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Intervention by retinoic acid in oxidative stress-induced apoptosis.
Retinoic acid (RA) has been considered a pro-apoptotic agent, and little is known about its anti-apoptotic potential. In this article, we describe that RA strongly inhibits hydrogen peroxideExpand
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Histone Deacetylase 3 Unconventional Splicing Mediates Endothelial-to-mesenchymal Transition through Transforming Growth Factor β2*
  • L. Zeng, G. Wang, +12 authors Q. Xu
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 17 September 2013
Background: Endothelial-to-mesenchymal transition (EndMT) is involved in embryonic cardiovascular development. Results: HDAC3 undergoes unconventional splicing during stem cell differentiation, whichExpand
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Characterization of neointima lesions associated with arteriovenous fistulas in a mouse model.
Arteriovenous fistulas (AVFs) are usually used for vascular access in the provision of hemodialysis, but AVFs have a 1-year patency rate of only about 60% owing to stenosis. As the molecularExpand
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Selective Roles of Retinoic Acid Receptor and Retinoid X Receptor in the Suppression of Apoptosis by All-trans-retinoic Acid*
Retinoic acids exert profound effects on many biological processes including cell proliferation, differentiation, and morphogenesis. We previously reported that all-trans-retinoic acid (t-RA)Expand
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Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality?
Research on herbal medicinal products is increasingly published in "Western" scientific journals dedicated primarily to conventional medicines. Publications are concerned mainly not only on theExpand
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Suppression of constitutive but not Il-1beta-inducible expression of monocyte chemoattractant protein-1 in mesangial cells by retinoic acids: intervention in the activator protein-1 pathway.
Retinoic acid regulates a wide range of biologic processes, including inflammation. This study investigated the effect of all-trans-retinoic acid (t-RA) on the constitutive and cytokine-inducibleExpand
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