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Scheduled Short‐Term Prevention With Frovatriptan for Migraine Occurring Exclusively in Association With Menstruation
Objective.— This post hoc subgroup analysis evaluated scheduled short‐term preventive frovatriptan therapy for women with migraine occurring exclusively in association with menstruation (occurringExpand
Evaluation of the Tolerability of Switching Patients on Chronic Full μ-Opioid Agonist Therapy to Buccal Buprenorphine
TLDR
Chronic pain patients treated with around-the-clock full μ-opioid agonist therapy can be switched to buccal buprenorphine at approximately 50% of their full dose without an increased risk of opioid withdrawal or loss of pain control. Expand
Bioequivalence of oxymorphone extended release and crush-resistant oxymorphone extended release
TLDR
Oxy- CRF and Oxy-ER (5 mg and 40 mg) are bioequivalent under fasted and fed conditions, suggesting that Oxy-CRF will have clinical efficacy and safety equivalent to Oxy- ER. Expand
Efficacy and safety of an octreotide implant in the treatment of patients with acromegaly.
TLDR
In this pivotal phase 3 study, the octreotide implant maintained reduced blood levels of GH and IGF-I with continuousOctreotide release over 6 months, which was well tolerated. Expand
Characteristics of Menstrual vs Nonmenstrual Migraine: A Post Hoc, Within‐Woman Analysis of the Usual‐Care Phase of a Nonrandomized Menstrual Migraine Clinical Trial
TLDR
Using a within‐woman analysis, the severity, duration, and relapse of menstrual vs nonmenstrual episodes of migraine during treatment with usual migraine therapy is compared. Expand
Comparison of the effectiveness and tolerability of lidocaine patch 5% versus celecoxib for osteoarthritis-related knee pain: post hoc analysis of a 12 week, prospective, randomized,
TLDR
Statistically significant differences in effectiveness and tolerability were not found between these 2 treatments in these patients with OA knee pain and a post hoc analysis of the available data is presented here. Expand
Treatment satisfaction in osteoarthritis and chronic low back pain: the role of pain, physical and emotional functioning, sleep, and adverse events.
TLDR
The results of multivariate analyses indicated that improvements in measures of pain intensity, pain relief, and interference with physical functioning each made independent contributions to treatment satisfaction in both groups of patients. Expand
Efficacy and tolerability of buccal buprenorphine in opioid-naive patients with moderate to severe chronic low back pain
TLDR
These findings demonstrate the efficacy and tolerability of BBUP among opioid-naive patients requiring around-the-clock opioid treatment for CLBP. Expand
Efficacy and tolerability of buccal buprenorphine in opioid-experienced patients with moderate to severe chronic low back pain: results of a phase 3, enriched enrollment, randomized withdrawal study
TLDR
Findings demonstrate the efficacy and tolerability of BBUP in opioid-experienced patients taking around-the-clock opioid treatment for chronic low back pain. Expand
Evaluation of the Pharmacokinetics of Single- and Multiple-dose Buprenorphine Buccal Film in Healthy Volunteers.
TLDR
The pharmacokinetic results suggest that therapeutic buprenorphine plasma concentrations can be obtained with BBUP across a wide dose range in a shorter time than other (eg, transdermal) dosage forms. Expand
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