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The 19q13 KRAB Zinc-finger protein ZFP82 suppresses the growth and invasion of esophageal carcinoma cells through inhibiting NF-κB transcription and inducing apoptosis.
ZFP82 is a tumor suppressor and is disrupted by promoter CpG methylation during esophageal carcinogenesis and is correlated with age, tumor stage and outcome. Expand
The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest
It is suggested that DACT2 promoter methylation is a potential epigenetic biomarker for the detection and chemotherapy guidance of NPC, while it inhibits NPC cell proliferation and metastasis via suppressing β-catenin/Cdc25c signaling. Expand
ADAMTS9 is Silenced by Epigenetic Disruption in Colorectal Cancer and Inhibits Cell Growth and Metastasis by Regulating Akt/p53 Signaling
Exogenous expression of ADAMTS9 in colorectal cancer cell lines inhibited cell proliferation and migration through the regulation of cell cycle and apoptosis and prevented the activation of Akt, and its downstream targets in colOREctalcancer cell lines. Expand
KRAB zinc-finger protein 382 regulates epithelial-mesenchymal transition and functions as a tumor suppressor, but is silenced by CpG methylation in gastric cancer
The findings of this study suggest that ZNF382 functions as a tumor suppressor in GC cells, but is frequently methylated in both GC cell lines and primary gastric tumors. Expand
Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer
The critical role of DRD2 is revealed in educating M1 macrophages, restricting NF-κB signaling pathway and triggering different processes of programmed cell death in BrCa, revealing a predictive and therapeutic target for BrCa. Expand
DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis
This study for the first time indicates ZDHHC1 is a potential tumor-suppressor frequently silenced due to promoter methylation, capable of negatively regulating metabolisms of tumor cells while stimulating oxidative stress and ER stress to expedite cell death through induction of pyroptosis and apoptosis, which can be exploited for development of new cancer prevention and therapies. Expand
ZBTB28 induces autophagy by regulation of FIP200 and Bcl-XL facilitating cervical cancer cell apoptosis
  • Li Li, Yijia Gong, +11 authors T. Xiang
  • Medicine
  • Journal of experimental & clinical cancer…
  • 30 April 2021
Findings identify ZBTB28 as a tumor suppressor gene that can induce autophagy-related apoptosis in cervical cancer cells, and may be a target for the treatment of uterine-cervical carcinoma. Expand
The zinc finger protein GATA4 induces mesenchymal‐to‐epithelial transition and cellular senescence through the nuclear factor‐κB pathway in hepatocellular carcinoma
This study explored the function of GATA4 in HCC and found a new therapeutic target for HCC, which is considered as a promising treatment option for cancer. Expand
The phosphoinositide hydrolase phospholipase C delta1 inhibits epithelial‐mesenchymal transition and is silenced in colorectal cancer
Insight is provided into the role of PLCD1 as a tumor suppressor gene in colorectal cancer (CRC), and it is demonstrated that it plays significant roles in proliferation, migration, invasion, cell cycle progression, and epithelial‐mesenchymal transition. Expand
Change in smoking behaviour of people who suffer from respiratory disease.
The smoking cessation rate among participants suffering from NSCLC, COPD and PTB increased after diagnosis compared with that before diagnosis, and was significantly higher than the control group of healthy individuals. Expand