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Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients.
The results suggest that the two XPD polymorphisms have a modulating effect on DRC, especially in the cases, and the pattern was less evident among the controls, although there was a nonsignificant 41% increase in the risk of suboptimal DRC for controls who were homozygous at either locus.
Interaction between Tobacco and Alcohol Use and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium
- M. Hashibe, P. Brennan, P. Boffetta
- MedicineCancer Epidemiology Biomarkers & Prevention
- 1 February 2009
It is confirmed that the joint effect between tobacco and alcohol use is greater than multiplicative on head and neck cancer risk, however, a substantial proportion of head and head cancers cannot be attributed to tobacco or alcohol use, particularly for oral cavity cancer and for head andneck cancer among women and among young-onset cases.
Association and Interactions between DNA Repair Gene Polymorphisms and Adult Glioma
Results suggest that polymorphisms in DNA repair genes may act individually or together to contribute to glioma risk.
Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer
A polymorphic tandem repeats minisatellite is identified in the downstream region of the human telomerase gene locus and was demonstrated to have promoter activity and a potential role of MNS16A in lung cancer susceptibility is suggested.
A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer.
- Hongbing Shen, Luo-nan Wang, M. Spitz, W. Hong, L. Mao, Q. Wei
- Biology, MedicineCancer research
- 1 September 2002
The results suggest that this novel variant of DNMT3B is associated with increased risk of lung cancer and may contribute to identifying individuals genetically susceptible to tobacco-induced cancers.
A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer
The results showed that the functional SNP −77T>C in XRCC1 5′UTR was associated with cancer development owing to the decreased transcriptional activity of C-allele-containing promoter with higher affinity to Sp1 binding.
Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review.
A Human Genome Epidemiology review on these three genes and a pooled analysis of published studies on ADH1C suggested the potential for a consortium of investigators conducting studies in this field.
Modulation of repair of ultraviolet damage in the host-cell reactivation assay by polymorphic XPC and XPD/ERCC2 genotypes.
This report investigated the association between the repair phenotype of ultraviolet (UV)-induced damage and genotypes of three DNA repair genes, XPC and XPD and XRCC1 and concluded that these NER polymorphisms may modulate DRC and may be useful biomarkers for identifying individuals at risk of developing cancer.
Identification of Genetic Variants in Base Excision Repair Pathway and Their Associations with Risk of Esophageal Squamous Cell Carcinoma
The results suggest that the polymorphisms in five BER genes may be associated with the susceptibility to ESCC in a Chinese population.
Genetic variants in selected pre‐microRNA genes and the risk of squamous cell carcinoma of the head and neck
The authors hypothesized that common polymorphisms in pre‐miRNAs are associated individually and (more likely) collectively with the risk of squamous cell carcinoma of the head and neck (SCCHN).