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Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation.
  • D. Li, Q. Wang, +20 authors W. Chen
  • Medicine, Biology
  • Toxicological sciences : an official journal of…
  • 1 February 2012
Identification of aberrant microRNA (miRNA) expression during chemical carcinogen-induced cell transformation will lead to a better understanding of the substantial role of miRNAs in cancerExpand
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Estrogen stimulation of ovarian surface epithelial cell proliferation
SummaryOvarian cancer is the leading cause of gynecological cancer mortality, and 85–90% of this malignancy originates from the ovarian surface epithelium (OSE). The etiology of ovarian epithelialExpand
  • 105
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UXT is a novel centrosomal protein essential for cell viability.
Ubiquitously expressed transcript (UXT) is a prefoldinlike protein that has been suggested to be involved in human tumorigenesis. Here, we have found that UXT is overexpressed in a number of humanExpand
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Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-alpha-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation.
Anthocyanins are naturally occurring plant pigments and exhibit an array of pharmacological properties. Our previous study showed that black rice pigment extract rich in anthocyanin prevents andExpand
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METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance
Objective N6-methyladenosine (m6A) RNA methylation and its associated methyltransferase METTL3 are involved in tumour initiation and progression via the regulation of RNA function. This studyExpand
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Accelerated cellular senescence in solid tumor therapy.
Accelerated cellular senescence (ACS) is an emerging concept that implicates sustained, telomere-independent cell cycle arrest of neoplastic cells in response to chemotherapeutic agents, ionizingExpand
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Soluble Interleukin-6 Receptor-Mediated Innate Immune Response to DNA and RNA Viruses
ABSTRACT The interleukin-6 (IL-6) receptor, which exists as membrane-bound and soluble forms, plays critical roles in the immune response. The soluble IL-6 receptor (sIL6R) has been identified as aExpand
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Endoplasmic Reticulum Protein SCAP Inhibits Dengue Virus NS2B3 Protease by Suppressing Its K27-Linked Polyubiquitylation
  • H. Liu, L. Zhang, +7 authors Chen Wang
  • Biology, Medicine
  • Journal of Virology
  • 22 February 2017
ABSTRACT Dengue viruses (DENVs) are an emerging threat to global public health. The NS2B3 protease complex of DENV has recently been shown to cleave the antiviral protein STING and thereby subvertExpand
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Cutting Edge: CTLA-4Ig Inhibits Memory B Cell Responses and Promotes Allograft Survival in Sensitized Recipients
Sensitized recipients with pretransplant donor-specific Abs are at higher risk for Ab-mediated rejection than nonsensitized recipients, yet little is known about the properties of memory B cells thatExpand
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Aberrant histone modification in peripheral blood B cells from patients with systemic sclerosis.
  • YaoYao Wang, Y. Yang, +9 authors R. Xiao
  • Biology, Medicine
  • Clinical immunology
  • 1 October 2013
OBJECTIVES To investigate alterations in histone modifications in B cells and their role in the pathogenesis of systemic sclerosis (SSc). METHODS Global histone H3/H4 acetylation and H3K4/H3K9Expand
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