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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
The oyster genome reveals stress adaptation and complexity of shell formation
The sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy and transcriptomes of development and stress response and the proteome of the shell are reported, showing that shell formation in molluscs is more complex than currently understood and involves extensive participation of cells and their exosomes.
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA
It is shown that MIR168a could bind to the human/mouse low-density lipoprotein receptor adapter protein 1 (LDLRAP1) mRNA, inhibit LDLRAP1 expression in liver, and consequently decrease LDL removal from mouse plasma, demonstrating that exogenous plant miRNAs in food can regulate the expression of target genes in mammals.
Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex
Results suggest that in the m6A MTase complex, METTL3 primarily functions as the catalytic core, while METTL14 serves as an RNA-binding platform, reminiscent of the target recognition domain of DNA N6-adenine MTase.
Satellite-to-ground quantum key distribution
This work reports the development and launch of a low-Earth-orbit satellite for implementing decoy-state QKD—a form ofQKD that uses weak coherent pulses at high channel loss and is secure because photon-number-splitting eavesdropping can be detected.
BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells
The studies revealed that BRCA1 represses Myc-mediated transcription while having no effect on some other transcriptional activities, and reverses the phenotype of embryonic fibroblasts transformed by the activation of Myc and Ras, but only minimally affects the transformed phenotype induced by SV40 virus.
Elevated ATPase Activity of KaiC Applies a Circadian Checkpoint on Cell Division in Synechococcus elongatus
miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130
Data indicate that miR-17-92 promotes adipocyte differentiation by targeting and negatively regulating Rb2/p130, a miRNA cluster that promotes cell proliferation in various cancers.
Isolation and Characterization of Adenoviruses Persistently Shed from the Gastrointestinal Tract of Non-Human Primates
The high degree of asymptomatic shedding of live adenovirus in non-human primates and evidence for zoonotic transmissions warrants caution for primate handling and housing, and the presence of persistent and/or latent adnovirus infections in the gut should be considered in the design and interpretation of human and non- human primate studies with adanovirus vectors.
Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6
The essential function of the SENP family is identified as an intrinsic attenuator of the TLR-triggered inflammation by catalyzing the de-SUMOylation of NEMO.