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Neuroprotective Function of the PGE2 EP2 Receptor in Cerebral Ischemia
TLDR
In the middle cerebral artery occlusion-reperfusion model of transient forebrain ischemia, genetic deletion of the EP2 receptor significantly increased cerebral infarction in cerebral cortex and subcortical structures, suggesting a novel mechanism of neuroprotection mediated by a dominant PGE2 receptor subtype in brain that may provide a target for therapeutic intervention. Expand
The role of parents' control in early adolescents' psychological functioning: a longitudinal investigation in the United States and China.
TLDR
The beneficial effects of parents' psychological autonomy support were generally stronger in the United States than in China, and parents' behavioral control predicted children's enhanced academic functioning. Expand
Neutrophils sense microbial size and selectively release neutrophil extracellular traps in response to large pathogens
TLDR
It is found that neutrophils sensed microbe size and selectively released neutrophil extracellular traps (NETs) in response to large pathogens, such as Candida albicans hyphae andextracellular aggregates of Mycobacterium bovis, but not inresponse to small yeast or single bacteria. Expand
A cone-beam computed tomography study of maxillary first permanent molar root and canal morphology in a Chinese population.
TLDR
Cone-beam computed tomography scanning is an effective method for studying external and internal dental morphology of permanent maxillary first molars in this Chinese population and more attention should be given to the detection of additional canals in patients between 20 and 30 years of age. Expand
Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity.
TLDR
Analysis of plasma kynurenine/tryptophan levels in patients with cancer affirms that the IDO pathway is activated in multiple tumor types and suggests that selective inhibition of IDO1 may represent an attractive cancer therapeutic strategy via up-regulation of cellular immunity. Expand
Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP‐9
Aim:  To investigate the status of Phosphatidylinositol 3‐kinase (PI3K)/PTEN/AKT/mammalian target of rapamycin (mTOR) pathway and its correlation with clinicopathological features and matrixExpand
PGE2 receptors rescue motor neurons in a model of amyotrophic lateral sclerosis
TLDR
An unexpected neuroprotective effect mediated by PGE2 is demonstrated, in which activation of its EP2 and EP3 receptors protected motor neurons from chronic glutamate toxicity. Expand
Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression.
TLDR
The results show how prostate cancer cells respond to demands for increased essential amino acids by coordinately activating amino acid transporter pathways vital for tumor outgrowth. Expand
The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis
TLDR
This work tested whether EP2 signaling participated in disease pathogenesis in the G93A superoxide dismutase (SOD) model of familial ALS and found that it did. Expand
Deletion of the Prostaglandin E2 EP2 Receptor Reduces Oxidative Damage and Amyloid Burden in a Model of Alzheimer's Disease
TLDR
The results indicate that PGE2 signaling via the EP2 receptor promotes age-dependent oxidative damage and increased Aβ peptide burden in this model of AD, possibly via effects on BACE1 activity. Expand
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