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SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes*
It is reported here that murine SIRT3 is expressed in brown adipose tissue and is localized on the mitochondria inner membrane, and plays an important role in adaptive thermogenesis inbrown adipose. Expand
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
It is reported here that the expression of SIRT2 is elevated in the white adipose tissue and kidney of caloric‐restricted mice and it is demonstrated that SIRT3a binds to FOXO3a and reduces its acetylation level, which increases FOXO DNA binding and elevates theexpression of FOXO target genes. Expand
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
It is reported here that SIRT3 responds dynamically to both exercise and nutritional signals in skeletal muscle to coordinate downstream molecular responses, and it is shown that exercise training increases Sirt3 expression as well as associated CREB phosphorylation and PGC-1α up-regulation. Expand
COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression
Hydroxychloroquine (HCQ), which exhibits an antiviral effect highly similar to that of CQ, could serve as a better therapeutic approach and is likely to attenuate the severe progression of COVID-19, inhibiting the cytokine storm by suppressing T cell activation. Expand
Interaction between GATA and the C/EBP Family of Transcription Factors Is Critical in GATA-Mediated Suppression of Adipocyte Differentiation
Results show that in addition to its previously recognized function in suppressing PPARγ transcriptional activity, interaction of GATA factors with C/EBP is necessary for their ability to negatively regulate adipogenesis. Expand
SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma.
  • F. Wang, Q. Tong
  • Biology, Medicine
  • Molecular biology of the cell
  • 26 November 2008
The results indicate that SIRT2 responds to nutrient deprivation and energy expenditure to maintain energy homeostasis by promoting lipolysis and inhibiting adipocyte differentiation. Expand
Function of GATA transcription factors in preadipocyte-adipocyte transition.
It is shown that murine GATA-2 and Gata-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation. Expand
Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria.
The findings constitute the first evidence of the regulation of Complex II activity by the reversible acetylation of the SdhA subunit as a novel substrate of the NAD(+)-dependent deacetylase, SIRT3. Expand
The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation.
It is shown that SirT2 regulates H4K20me1 deposition through the deacetylation of H 4K16Ac and determines the levels of H4 k20me2/3 throughout the cell cycle and upon stress, the interaction betweenSirT2 and PR-Set7 increases along with the H4k20me 1 levels, suggesting a novel mitotic checkpoint mechanism. Expand
Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
The elevation of SIRT1 and Skp2 expression in malignant PC3 and DU145 prostate cells is responsible for the downregulation of FOXO3 protein levels in these cells, and data support the notion that deacetylation of FoxO3 by SIRT 1 or SIRT2 facilitatesSkp2-mediated FOXO 3 poly-ubiquitination and proteasomal degradation. Expand