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Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. The kinase inhibitor nintedanib specific for vascular endothelial growth factor receptor (VEGFR),… Expand
Macrophage recruitment in obese adipose tissue
Obesity is characterized as a chronic state of low‐grade inflammation with progressive immune cell infiltration into adipose tissues. Adipose tissue macrophages play critical roles in the… Expand
A novel long noncoding RNA Lnc‐HC binds hnRNPA2B1 to regulate expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol metabolism
Cholesterol metabolism disorder in hepatocytes predicts a higher risk of metabolic syndrome (MetS). Long noncoding RNAs (lncRNAs) have emerged as critical players in cellular cholesterol metabolism,… Expand
Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats.
- M. Shahzad, X. Yang, +5 authors Shemin Lu
- Biology, Medicine
- Pulmonary pharmacology & therapeutics
- 1 February 2009
The black seeds, from the Ranunculaceae family, have been traditionally used by various cultures as a natural remedy for several ailments. In this study, we examined the effect of black seed oil as… Expand
TLR3 and TLR7 Modulate IgE Production in Antigen Induced Pulmonary Inflammation via Influencing IL-4 Expression in Immune Organs
Background Toll-like receptors (TLRs) as pattern recognition receptors, participate in both innate and adaptive immune responses, and seem to play an important role in the pathogenesis of asthma.… Expand
BST-2 expression in human hepatocytes is inducible by all three types of interferons and restricts production of hepatitis C virus.
Bone marrow stromal cell antigen 2 (BST-2, also known as tetherin, CD317, or HM1.24) has recently been identified as a host restriction factor against diverse families of enveloped viruses. However,… Expand
PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation
Protein arginine methyltransferase (PRMT)1, methylating both histones and key cellular proteins, has emerged as a key regulator of various cellular processes. This study aimed to identify the… Expand
Pdcd4 modulates markers of macrophage alternative activation and airway remodeling in antigen‐induced pulmonary inflammation
Pdcd4 has been known as a tumor‐suppressor gene initially and is up‐regulated during apoptosis. Surprisingly, we found that Pdcd4 was differentially expressed in the lung from E3 rats with AIPI, an… Expand
Suppressive effects of black seed oil on ovalbumin induced acute lung remodeling in E3 rats.
OBJECTIVE Black seed oil (BSO) is widely used as a traditional medicine for asthma and other inflammatory diseases. The aim of this study is to evaluate the effects of BSO on ovalbumin (OVA) induced… Expand
Extracellular microRNA-21 and microRNA-26a increase in body fluids from rats with antigen induced pulmonary inflammation and children with recurrent wheezing
BackgroundThis study aims to find out whether extracellular miRNAs is implicated in recurrent childhood wheezing with asthmatic risk.MethodsOne hundred and forty children of Chinese Han population… Expand