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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
- K. O'reilly, F. Rojo, N. Rosen
- Biology, ChemistryCancer research
- 1 February 2006
TLDR
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
- L. Saal, P. Johansson, R. Parsons
- BiologyProceedings of the National Academy of Sciences
- 1 May 2007
TLDR
4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors.
- Q. She, Ensar Halilovic, N. Rosen
- Biology, MedicineCancer cell
- 13 July 2010
ERKs and p38 Kinase Phosphorylate p53 Protein at Serine 15 in Response to UV Radiation*
TLDR
Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt…
- Q. She, D. Solit, A. Basso, M. Moasser
- Biology, MedicineClinical cancer research : an official journal of…
- 1 October 2003
TLDR
Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase.
TLDR
A simple HPLC method for the determination of S-adenosylmethionine and S-adenosylhomocysteine in rat tissues: the effect of vitamin B6 deficiency on these concentrations in rat liver.
- Q. She, I. Nagao, T. Hayakawa, H. Tsuge
- ChemistryBiochemical and biophysical research…
- 30 December 1994
TLDR
Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring V600EBRAF
- F. Xing, Y. Persaud, D. Solit
- Biology, MedicineOncogene
- 26 January 2012
TLDR
Breast Tumor Cells with PI3K Mutation or HER2 Amplification Are Selectively Addicted to Akt Signaling
- Q. She, S. Chandarlapaty, N. Rosen
- Biology, MedicinePloS one
- 26 August 2008
TLDR
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