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Identification of microRNAs in human follicular fluid: characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo.
CONTEXT Human follicular fluid is a combination of proteins, metabolites, and ionic compounds that is indicative of the general state of follicular metabolism and is associated with maturation andExpand
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Mutations in TUBB8 and Human Oocyte Meiotic Arrest.
Background Human reproduction depends on the fusion of a mature oocyte with a sperm cell to form a fertilized egg. The genetic events that lead to the arrest of human oocyte maturation are unknown.Expand
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Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility.
  • Q. Sang, B. Li, +14 authors L. Wang
  • Biology, Medicine
  • American journal of human genetics
  • 5 April 2018
Fertilization is a fundamental process of development and is a prerequisite for successful human reproduction. In mice, although several receptor proteins have been shown to play important roles inExpand
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Novel mutations and structural deletions in TUBB8: expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development
STUDY QUESTION Are there any new type of mutations and novel phenotypes in patients with arrest in oocyte maturation, fertilization or early embryonic development having tubulin beta eight class VIIIExpand
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Biallelic Mutations in PATL2 Cause Female Infertility Characterized by Oocyte Maturation Arrest.
Oocyte maturation arrest results in female infertility, but the genetic determinants of human oocyte maturation arrest remain largely unknown. Previously, we identified TUBB8 mutations responsibleExpand
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A possible new mechanism in the pathophysiology of polycystic ovary syndrome (PCOS): the discovery that leukocyte telomere length is strongly associated with PCOS.
  • Q. Li, J. Du, +8 authors L. Wang
  • Biology, Medicine
  • The Journal of clinical endocrinology and…
  • 1 February 2014
CONTEXT Telomeres are specialized chromatin structures located at the ends of eukaryotic chromosomes, and telomere length plays a clear role in various diseases. However, it is not known whetherExpand
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A pannexin 1 channelopathy causes human oocyte death
Inherited dominant mutations in PANX1 cause female infertility characterized by oocyte death. A vital gene for oocytes Infertility is common in both males and females, but the biological causes ofExpand
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Manometric heterogeneity in patients with idiopathic achalasia.
BACKGROUND & AIMS In certain cases of achalasia, particularly those in early stages with minimal endoscopic or radiographic abnormalities, the diagnosis may rely on manometry, which is the mostExpand
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Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest.
Early embryonic arrest is one of the major causes of female infertility. However, because of difficulties in phenotypic evaluation, genetic determinants of human early embryonic arrest are largelyExpand
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Molecular cloning, characterization and expression profiles of three estrogen receptors in protogynous hermaphroditic orange-spotted grouper (Epinephelus coioides).
Estrogen plays key roles in vertebrate reproductive system via estrogen receptors (ERs) as mediating pathways. In the present study, three full-length ERs cDNA sequences were isolated from aExpand
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