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Identification of microRNAs in human follicular fluid: characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo.
- Q. Sang, Zhongyuan Yao, +8 authors L. Wang
- Biology, Medicine
- The Journal of clinical endocrinology and…
- 10 May 2013
CONTEXT
Human follicular fluid is a combination of proteins, metabolites, and ionic compounds that is indicative of the general state of follicular metabolism and is associated with maturation and… Expand
Mutations in TUBB8 and Human Oocyte Meiotic Arrest.
- Ruizhi Feng, Q. Sang, +30 authors L. Wang
- Biology, Medicine
- The New England journal of medicine
- 20 January 2016
Background Human reproduction depends on the fusion of a mature oocyte with a sperm cell to form a fertilized egg. The genetic events that lead to the arrest of human oocyte maturation are unknown.… Expand
Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility.
Fertilization is a fundamental process of development and is a prerequisite for successful human reproduction. In mice, although several receptor proteins have been shown to play important roles in… Expand
Novel mutations and structural deletions in TUBB8: expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development
STUDY QUESTION Are there any new type of mutations and novel phenotypes in patients with arrest in oocyte maturation, fertilization or early embryonic development having tubulin beta eight class VIII… Expand
Biallelic Mutations in PATL2 Cause Female Infertility Characterized by Oocyte Maturation Arrest.
- B. Chen, Z. Zhang, +15 authors L. Wang
- Biology, Medicine
- American journal of human genetics
- 5 October 2017
Oocyte maturation arrest results in female infertility, but the genetic determinants of human oocyte maturation arrest remain largely unknown. Previously, we identified TUBB8 mutations responsible… Expand
A possible new mechanism in the pathophysiology of polycystic ovary syndrome (PCOS): the discovery that leukocyte telomere length is strongly associated with PCOS.
- Q. Li, J. Du, +8 authors L. Wang
- Biology, Medicine
- The Journal of clinical endocrinology and…
- 1 February 2014
CONTEXT
Telomeres are specialized chromatin structures located at the ends of eukaryotic chromosomes, and telomere length plays a clear role in various diseases. However, it is not known whether… Expand
A pannexin 1 channelopathy causes human oocyte death
Inherited dominant mutations in PANX1 cause female infertility characterized by oocyte death. A vital gene for oocytes Infertility is common in both males and females, but the biological causes of… Expand
Manometric heterogeneity in patients with idiopathic achalasia.
BACKGROUND & AIMS
In certain cases of achalasia, particularly those in early stages with minimal endoscopic or radiographic abnormalities, the diagnosis may rely on manometry, which is the most… Expand
Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest.
- Y. Xu, Yingli Shi, +14 authors L. Wang
- Biology, Medicine
- American journal of human genetics
- 1 September 2016
Early embryonic arrest is one of the major causes of female infertility. However, because of difficulties in phenotypic evaluation, genetic determinants of human early embryonic arrest are largely… Expand
Molecular cloning, characterization and expression profiles of three estrogen receptors in protogynous hermaphroditic orange-spotted grouper (Epinephelus coioides).
- Huapu Chen, Y. Zhang, +9 authors H. Lin
- Biology, Medicine
- General and comparative endocrinology
- 1 July 2011
Estrogen plays key roles in vertebrate reproductive system via estrogen receptors (ERs) as mediating pathways. In the present study, three full-length ERs cDNA sequences were isolated from a… Expand