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Contribution of heavy metals to toxicity of coal combustion related fine particulate matter (PM2.5) in Caenorhabditis elegans with wild-type or susceptible genetic background.
TLDR
Toxicity from the combinational exposure to Pb, Cr, and Cu at the examined concentrations was higher than exposure to PM2.5 (100 mg/L), and mutation of sod-2 or sod-3 gene encoding Mn-SOD increased susceptibility in nematodes exposed to Fe, Zn, or Ni, although Fe,Zn,or Ni at the examine concentration did not lead to toxicity in wild-type nematode. Expand
Toxicity and translocation of graphene oxide in Arabidopsis thaliana.
TLDR
The data imply that although GO was absorbed by Arabidopsis plants through root hairs, plants might still have strong ability to be against GO translocation into stem or leaves, and cotyledon might serve as an important site for GO distribution during the early development. Expand
Metallothioneins Are Required for Formation of Cross-Adaptation Response to Neurobehavioral Toxicity from Lead and Mercury Exposure in Nematodes
TLDR
The defects of adaptive response to neurobehavioral toxicity induced by metal Exposure could be completely rescued by the expression of mtl-1 and mTL-2 with the aid of their native promoters, which significantly suppressed the toxicity on locomotion behaviors from metal exposure at all examined concentrations. Expand
Enzymatic properties of the 20S proteasome in wheat endosperm and its biochemical characteristics after seed imbibition.
TLDR
The evidence suggests that the main role of the 20S proteasome may not be to degrade massive proteins of the wheat endosperm after seed imbibition. Expand
Biosafety assessment of titanium dioxide nanoparticles in acutely exposed nematode Caenorhabditis elegans with mutations of genes required for oxidative stress or stress response.
TLDR
The results suggest the relatively safe property of acute exposure to TiO2-NPs with certain durations at predicted environmental relevant concentrations or concentrations comparable to those in food in nematodes with mutations of some susceptible genes. Expand
Exposure to Lead and Mercury in Young Larvae Induces More Severe Deficits in Neuronal Survival and Synaptic Function than in Adult Nematodes
TLDR
The data suggest that neuronal survival in GABAergic neurons and cholinergic transmission were relatively stable during development in nematodes, and younger (L1–L3) larvae show more sensitivity to neurotoxicity of neuronal survival and synaptic function than L4 larvae and young adult nematode. Expand
Prolonged manganese exposure induces severe deficits in lifespan, development and reproduction possibly by altering oxidative stress response in Caenorhabditis elegans.
TLDR
Extended exposure to high concentrations of Mn will induce the severe defects of life span, development, and reproduction in nematodes possibly by affecting the stress response and expression of antioxidant genes in Caenorhabditis elegans. Expand
Aluminum nanoparticle exposure in L1 larvae results in more severe lethality toxicity than in L4 larvae or young adults by strengthening the formation of stress response and intestinal lipofuscin
TLDR
Al(2)O(3)-NPs exposure in L1 larvae causes more severe lethality toxicity than in L4 larvae or young adults by strengthening the formation of stress response and intestinal lipofuscin accumulation in nematodes. Expand
Close association of intestinal autofluorescence with the formation of severe oxidative damage in intestine of nematodes chronically exposed to Al(2)O(3)-nanoparticle.
TLDR
Chronic exposure to Al(2)O(3)-NPs may cause adverse effects on intestinal lipofuscin accumulation by inducing the formation of more severe oxidative stress in intestines than exposure in nematodes. Expand
A mir-231-Regulated Protection Mechanism against the Toxicity of Graphene Oxide in Nematode Caenorhabditis elegans
TLDR
Investigating the molecular mechanism of mir-231 in the regulation of GO toxicity using in vivo assay system of Caenorhabditis elegans found that GO exposure inhibited the expression ofmir-231::GFP in multiple tissues, in particular in the intestine. Expand
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