• Publications
  • Influence
A Long Noncoding RNA ZEB1-AS1 Promotes Tumorigenesis and Predicts Poor Prognosis in Glioma
  • Q. Lv, Lei Hu, +7 authors H. Zhou
  • Biology, Medicine
  • International journal of molecular sciences
  • 30 August 2016
ZEB1-AS1 functioned as an important regulator of migration and invasion via activating epithelial to mesenchymal transition (EMT) through up-regulating the expression of ZEB1, MMP2, M MP9, N-cadherin, and Integrin-β1 as well as decreasing E-c cadherin levels in the metastatic progression of glioma. Expand
Upregulation of long noncoding RNA zinc finger antisense 1 enhances epithelial–mesenchymal transition in vitro and predicts poor prognosis in glioma
  • Q. Lv, Shu-Hui Chen, +8 authors H. Zhou
  • Biology, Medicine
  • Tumour biology : the journal of the International…
  • 1 March 2017
It was found that silenced zinc finger antisense 1 could impair migration and invasion by inhibiting the epithelial–mesenchymal transition through reducing the expression of MMP2, MMP9, N-cadherin, Integrin β1, ZEB1, Twist, and Snail as well as increasing E-c cadherin level in glioma. Expand
Akt/FoxM1 signaling pathway-mediated upregulation of MYBL2 promotes progression of human glioma
MYBL2 is a key downstream factor of Akt/FoxM1 signaling to promote progression of humanglioma, and could be a new candidate gene for molecular targeting therapy and biomarker for radiotherapy of glioma. Expand
In Vitro and in Vivo Inhibitory Effects of Glycyrrhetinic Acid in Mice and Human Cytochrome P450 3A4
  • Q. Lv, Guihua Wang, +5 authors H. Zhou
  • Chemistry, Medicine
  • International journal of environmental research…
  • 25 December 2015
GA may exert herb-drug interactions by competitively inhibiting CYP3A4 in a dose- but not time-dependent manner, and it was observed that mRNA expressions of the Cyps2c and 3a family decreased significantly in the livers of mice treated with GA. Expand
NF-κB-Regulated miR-99a Modulates Endothelial Cell Inflammation
MiR-99a inhibited the LPS-induced HUVECs inflammation via inhibition of the mTOR/NF-κB signal and promoted the transcription of miR- 99a by binding to the −1643 to −1652 region of mi R99a promoter. Expand
Overexpression of RACK1 Promotes Metastasis by Enhancing Epithelial-Mesenchymal Transition and Predicts Poor Prognosis in Human Glioma
This study found that RACK1 was significantly up-regulated in glioma tissues compared with normal brain tissues, being closely related to clinical stage of gliomas both in mRNA and protein levels and demonstrated that patients with high Rack1 expression had a poor prognosis. Expand
Mechanism-based inhibition of Alantolactone on human cytochrome P450 3A4 in vitro and activity of hepatic cytochrome P450 in mice.
  • C. Qin, Q. Lv, +7 authors H. Zhou
  • Chemistry, Medicine
  • Journal of ethnopharmacology
  • 20 June 2015
The inhibitory effect of AL on cytochrome P450s in vitro and in vivo indicates that herb-drug interaction should be paid more attention between AL and drugs metabolized by CYP3A4. Expand
DNA hypermethylated status and gene expression of PAX1/SOX1 in patients with colorectal carcinoma
The hypermethylation of paired boxed gene 1 (PAX1) and sex-determining region Y-related high-mobility group box 1 (SOX1), which may be new biomarkers for CRC screening, is investigated in CRC tissues. Expand
Advances in molecular signaling mechanisms of β-phenethyl isothiocyanate antitumor effects.
This work focuses on the major molecular signaling pathways for the anticancer activities of PEITC and discusses the regulation of drug-metabolizing enzymes, including cytochrome P450s, metabolizing enzyme, and multidrug resistance. Expand
TRPM2‐AS inhibits the growth, migration, and invasion of gliomas through JNK, c‐Jun, and RGS4
The mechanisms of the participation of TRPM2‐AS in the progression of gliomas might, at least partly, be related to JNK, c‐Jun, and RGS4. Expand