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Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells
It is reported that treatment with both anti–PD-1 and anti–CTLA-4 antibodies was unable to eradicate large, modestly immunogenic CT26 tumors or metastatic 4T1 tumors, and cancers resistant to immune checkpoint blockade can be cured by eliminating MDSCs. Expand
Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis
It is speculated that in humans the circadian clock imposes regulation of epidermal cell proliferation so that skin is at a particularly vulnerable stage during times of maximum UV exposure, thus contributing to the high incidence of human skin cancers. Expand
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections
It is shown that avian influenza A H5N1-infected patients exhibit markedly increased serum levels of angiotensin II, which appears to be linked to the severity and lethality of infection, at least in some patients. Expand
Ischemic neurons recruit natural killer cells that accelerate brain infarction
  • Y. Gan, Q. Liu, +9 authors F. Shi
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 3 February 2014
It was discovered that NK cells infiltrated the brains of stroke patients and mice with induced stroke, and catalyzed neuronal death in the ischemic brain through NK cell-mediated exacerbation of brain infarction. Expand
Differential Activation of Innate Immune Responses by Adenovirus and Adeno-Associated Virus Vectors
Results show that AAV vectors activate the innate immune system to a lesser extent than do adenovirus vectors and offer a possible explanation for the reduced inflammatory properties of AAV compared to adeno-associated virus vectors. Expand
A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis.
A novel mouse model of IBD-colorectal cancer progression is established in which disrupted immune regulation, mTOR-Stat3 signaling, and epithelial hyperproliferation are integrated and simultaneously linked to the development of malignancy. Expand
Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core.
A specific amino acid residue (Phe(164)) within the FATG lipid droplet localization sequence of HCV-3a core protein played a major role in the stronger FAS activation by HCV 3a core. Expand
Activation of p38 and ERK Signaling during Adenovirus Vector Cell Entry Lead to Expression of the C-X-C Chemokine IP-10
The results demonstrate the importance of signaling via ERK and p38 in the early host response to adenovirus vectors and will permit the development of novel strategies to improve the safety and efficacy of these agents in human gene therapy. Expand
Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells
It is demonstrated that tumour-associated macrophages enhance the aerobic glycolysis and apoptotic resistance of breast cancer cells via the extracellular vesicle transmission of a myeloid-specific lncRNA, HIF-1α-stabilizing long noncoding RNA (HISLA). Expand
The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases
The redox-sensitive signaling system Keap1/Nrf2/ARE plays a key role in the maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and pro-apoptotic conditions, which allows us to consider it as a pharmacological target. Expand