• Publications
  • Influence
Impact of a competitive marathon race on systemic cytokine and neutrophil responses.
TLDR
Although many cytokines recruiting and priming neutrophils and monocytes were secreted and functional after exhaustive exercise, overwhelming antioxidant and antiinflammatory defenses were induced, preventing exercise-induced oxidative stress. Expand
CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3.
TLDR
It is shown that breast TAMs abundantly produce CCL18, and its expression in blood or cancer stroma is associated with metastasis and reduced patient survival, which indicates that CCL 18 derived from TAMs plays a critical role in promoting breast cancer metastasis via its receptor, PITPNM3. Expand
Circulating cytokines and hormones with immunosuppressive but neutrophil-priming potentials rise after endurance exercise in humans
TLDR
Results suggested that exercise-induced pathogenesis including previously reported immunosuppression and neutrophil hyper-reactivity might be attributed, at least partly, to the systemic dynamics of the above bioactive substances. Expand
Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1
TLDR
It is found that deletion of APP and its homolog APLP2, or components of the gamma-secretase complex, significantly enhanced the expression and function of LRP1, which was reversed by forced expression of the APP intracellular domain (AICD). Expand
A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.
TLDR
It is shown that mesenchymal-like breast cancer cells activate macrophages to a TAM-like phenotype by GM-CSF, which suggests that a positive feedback loop between GM- CSF and CCL18 is important in breast cancer metastasis. Expand
RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization.
TLDR
Evidence is presented suggesting that transforming growth factor-beta is an inducer of nuclear translocation of RUNX3, and RunX3 in the cytoplasm of cancer cells is inactive as a tumor suppressor. Expand
A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis.
TLDR
This work identifies an NF-KappaB Interacting LncRNA (NKILA), which is upregulated by NF-κB, binds to NF-σκB/IκBs, and directly masks phosphorylation motifs of IKKB, thereby inhibiting IKK-induced IκBosphorylation and NF-kkB activation. Expand
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
TLDR
It is concluded that anti-PCSK9 antibodies may be effective therapeutics for treating hypercholesterolemia. Expand
LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein
TLDR
It is shown that low-density lipoprotein receptor-related protein 1 (LRP1), which binds to multiple ligands through basic motifs, associates with PrPC during its endocytosis and is functionally required for this process, suggesting that LRP1 expedites the trafficking of PrPC to the neuronal surface. Expand
Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake
TLDR
It is demonstrated that LRP1 and HSPG function in a cooperative manner to mediate cellular Aβ uptake and define a major pathway through which Aβ gains entry to neuronal cells. Expand
...
1
2
3
4
5
...