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Genome-wide association study of circulating vitamin D levels
The primary circulating form of vitamin D, 25-hydroxy-vitamin D [25(OH)D], is associated with multiple medical outcomes, including rickets, osteoporosis, multiple sclerosis and cancer. In a… Expand
Pathway analysis by adaptive combination of P‐values
It is increasingly recognized that pathway analyses—a joint test of association between the outcome and a group of single nucleotide polymorphisms (SNPs) within a biological pathway—could potentially… Expand
Common Genetic Variants and Risk for HPV Persistence and Progression to Cervical Cancer
HPV infrequently persists and progresses to cervical cancer. We examined host genetic factors hypothesized to play a role in determining which subset of individuals infected with oncogenic human… Expand
Improved correction for population stratification in genome‐wide association studies by identifying hidden population structures
Hidden population substructure can cause population stratification and lead to false‐positive findings in population‐based genome‐wide association (GWA) studies. Given a large panel of markers… Expand
Efficient Approximation of P‐value of the Maximum of Correlated Tests, with Applications to Genome‐Wide Association Studies
A robust test, MAX, based on the maximum of three trend test statistics derived for recessive, additive, and dominant models, has been proposed recently. Expand
Flexible design for following up positive findings.
- K. Yu, N. Chatterjee, +4 authors S. Wacholder
- Computer Science, Medicine
- American journal of human genetics
- 1 September 2007
We apply a bootstrap procedure to correct the effect of regression to the mean, also called "winner's curse," resulting from choosing to follow up the markers with the strongest associations. Expand
An imputation-regularized optimization algorithm for high dimensional missing data problems and beyond.
- F. Liang, B. Jia, J. Xue, Q. Li, Ye Luo
- Mathematics, Medicine
- Journal of the Royal Statistical Society. Series…
- 1 November 2018
Missing data are frequently encountered in high dimensional problems, but they are usually difficult to deal with by using standard algorithms, such as the expectation-maximization algorithm and its… Expand
Population Substructure and Control Selection in Genome-Wide Association Studies
Determination of the relevance of both demanding classical epidemiologic criteria for control selection and robust handling of population stratification (PS) represents a major challenge in the… Expand
Detection of endometriosis with the use of plasma protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry.
In this prospective case-control study, we determined the role of surface-enhanced laser desorption and ionization time-of-flight mass spectrometry in the detection of histologically proven… Expand
Single Nucleotide Polymorphisms in the PRDX3 and RPS19 and Risk of HPV Persistence and Cervical Precancer/Cancer
BACKGROUND Host genetic factors might affect the risk of progression from infection with carcinogenic human papillomavirus (HPV), the etiologic agent for cervical cancer, to persistent HPV infection,… Expand