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Telomerase reverse transcriptase promotes epithelial–mesenchymal transition and stem cell-like traits in cancer cells
Telomerase activation through induction of telomerase reverse transcriptase (hTERT) contributes to malignant transformation by stabilizing telomeres. Clinical studies demonstrate that higher hTERT… Expand
Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer
The major goal of breast cancer prevention is to reduce the incidence of ductal carcinoma in situ (DCIS), an early stage of breast cancer. However, the biology behind DCIS formation is not well… Expand
Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer.
Green tea catechins have been reported to have antitumor activity. The objective of this study was to examine the effect of catechins on the antitumor efficacy of doxorubicin (DOX) in a murine model… Expand
Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis
Tumor–stromal interaction is a dynamic process that promotes tumor growth and metastasis via cell–cell interaction and extracellular vesicles. Recent studies demonstrate that stromal… Expand
Antineoplastic effect of β‐elemene on prostate cancer cells and other types of solid tumour cells
- Q. Li, G. Wang, F. Huang, M. Banda, E. Reed
- Chemistry, Medicine
- The Journal of pharmacy and pharmacology
- 1 August 2010
Objectives β‐Elemene, a natural compound extracted from over 50 different Chinese medicinal herbs and plants, has been effective in the treatment of hyperplastic and proliferative disorders such as… Expand
Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer (Review).
Cisplatin is one of the most potent anticancer agents, displaying significant clinical activity against a variety of solid tumors. For more than two decades, the most effective systemic chemotherapy… Expand
In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma.
- J. Zhao, Q. Li, +7 authors K. Gardner
- Biology, Medicine
- International journal of oncology
- 1 August 2007
Beta-elemene has recently raised interest in P.R. China as a novel antitumor plant drug isolated from the Chinese medicinal herb Zedoary. To explore potentially useful combinations of beta-elemene… Expand
Evaluation of cisplatin in combination with β-elemene as a regimen for prostate cancer chemotherapy.
- Q. Li, G. Wang, E. Reed, L. Huang, C. Cuff
- Basic & clinical pharmacology & toxicology
- 1 November 2010
Cisplatin is one of the most potent chemotherapeutic agents for the treatment of many types of solid tumours. Nevertheless, it is not the first-line drug for prostate cancer chemotherapy, because… Expand
Neuro-optic cell apoptosis and microangiopathy in KKAY mouse retina.
- Xia Ning, Qin Bao-yu, Liang Yu-zhen, S. Shu-li, E. Reed, Q. Li
- Biology, Medicine
- International journal of molecular medicine
Diabetic retinopathy is one of the common complications of diabetes and is the leading cause for patients' visual dysfunction and sight loss. However, the mechanism of diabetic retinopathy is not… Expand
Apoptosis in prostate cancer: progressive and therapeutic implications (Review).
Prostate cancer is the most common non-cutaneous malignancy in American men and the second greatest cause of cancer-related death. Development of effective therapeutic modalities for the treatment of… Expand