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Decreased thymidine kinase levels in peripheral blood cells from HIV-seropositive individuals: implications for zidovudine metabolism.
- B. Jacobsson, S. Britton, Q. He, A. Karlsson, S. Eriksson
- Biology, MedicineAIDS research and human retroviruses
- 1 July 1995
The reduced capacity for intracellular phosphorylation of AZT in HIV-infected individuals may be an important factor in the emergence of clinical AZT resistance and should also be accounted for in testingAZT resistance in vitro with PBMCs from healthy blood donors.
A novel aminosteroid is active for proliferation inhibition and differentiation induction of human acute myeloid leukemia HL-60 cells.
Effects of Pleiotrophin (PTN) Over-expression on Mouse Long Bone Development, Fracture Healing and Bone repair
It is confirmed that the targeted PTN over-expression in mouse bone has moderate enhancing effects on early bone development; but the bones become brittle in later life.
The effects and mechanisms of a novel 2-aminosteroid on murine WEHI-3B leukemia cells in vitro and in vivo.
Preservation of immunorecognition by transferring cells from 10% neutral buffered formalin to 70% ethanol
In two cell lines, immunorecognition decreased between 18 and 36 h of fixation in 10% NBF for PCNA, Ki67-MIB-1 and cytokeratins AE1/AE3, and the effects on EGFr immunoreCognition were less.
[Synthesis of 2 beta-(4'-methyl-1'-piperazino)-3 alpha-hydroxyl-16,17- substituted-5 alpha-androstanes].
Preliminary results of biological experiment showed that the vicinal amino-alcohol compounds of 5 alpha-androstane possess to a different extent antiarrhythmic activities among which compounds VI, XI and XIV showed higher activities than others.
[AP-1 mediated signal transduction in thrombin-induced regulation of PAL-1 expression in human mesangial cells].
It is indicated that in cultured human MCs, thrombin stimulates PAI-1 expression through an AP-1 signal pathway, which may be mediated by PKC and PTK.
[Effect of a novel aminosteroid on animal model of murine myelomonocytic leukemia].
- X. Na, Q. He, D. Jiang
- Biology, MedicineHunan yi ke da xue xue bao = Hunan yike daxue…
- 28 February 2000
It is suggested that leukemia mice could be effectively treated by the novel aminosteroid and the efficacy maybe paralleled with the dosage of the novelAminosteroids.
Introduction Single Slab 3D turbo spin echo sequence with variable refocusing flip angles (aka SPACE) [1, 2, and 3] has been optimized for PDw, T2w and T1w contrast imaging. In order to obtain 3D…
THE OSTEOGENIC POTENTIAL OF A RAT PERIPHERAL BLOOD MONONUCLEAR CELL SUBSET
It is shown that these circulating stem cells possess osteogenic potential in vitro and in vivo and further work is ongoing to investigate the roles of PBMNCs subset in fracture healing and their recruiting and homing mechanisms.