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Hsa_circ_0137008 suppresses the malignant phenotype in colorectal cancer by acting as a microRNA-338-5p sponge
TLDR
The fact that overexpression of hsa_circ_0137008 inhibited the progression of CRC via sponging miR-338-5p is suggested to be a principal regulator of CRC tumorigenesis. Expand
The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo.
TLDR
The collective results support the critical involvement of NCoR1 in normal and malignant hematopoiesis in vivo and reveal that several he matopoietic-associated genes are regulated by N coR1. Expand
MiR-141 promotes cell proliferation and invasion in non-small cell lung cancer by targeting KLF9.
TLDR
MiR- 141 promoted the proliferation and invasion by targeting the KLF9 in non-small cell lung cancer, and the newly identified miR-141/KLF9 axis provides novel insight into the pathogenesis of non- Small Cell lung cancer. Expand
LncRNA SNHG17 aggravated prostate cancer progression through regulating its homolog SNORA71B via a positive feedback loop
TLDR
It is revealed that lncRNA SNHG17 aggravated prostate cancer progression through regulating its homolog SNORA71B via a positive feedback loop, which might do help to the pursuit of better PC treatment. Expand
TAZ is overexpressed in prostate cancers and regulates the proliferation, migration and apoptosis of prostate cancer PC3 cells.
TLDR
Experimental results indicate that TAZ plays a significant role in the proliferation, migration and apoptosis of prostate cancer cells and could be a useful biomarker for PCa diagnosis/prognosis and a potential target for the treatment of prostate cancers. Expand
miR-342-5p promotes Zmpste24-deficient mouse embryonic fibroblasts proliferation by suppressing GAS2
TLDR
Findings suggest that downregulated miR-342-5p is involved in regulating cell proliferation and cell cycles in Zmpste24−/− MEFs by suppressing GAS2 in vitro. Expand
LncRNA NEAT1 regulates proliferation, apoptosis and invasion of liver cancer.
  • J. Kou, J. Ma, +7 authors Q. He
  • Chemistry, Medicine
  • European review for medical and pharmacological…
  • 1 April 2020
TLDR
Down-regulation of LncRNA NEAT1 can inhibit EGFR expression and promote hepatoma cell apoptosis, inhibit cell cycle, thus inhibiting tumor proliferation and invasion. Expand
T851I mutation of human large tumor suppressor 1 disrupts its kinase activity and tumor-suppressor functions.
TLDR
It is proposed that T851 is an active residue other than Ser909 on the activation loop and is essential for LATS1 phosphorylation and kinase activity and uncovers the T8 51I mutation of LATS 1 and consequent Hippo signaling suppression as a hitherto uncharacterized mechanism controlling colorectal tumorigenesis. Expand
Low expression of lncRNA MGC27345 is associated with poor prognosis in gastric cancer patients.
TLDR
The data indicated that MGC27345 may have a diagnostic and prognostic value for patients with advanced gastric cancer and assist to improve clinical outcomes for GC patients. Expand
MicroRNA-138 Regulates T-Cell Function by Targeting PD-1 in Patients with Hepatitis B Virus-Related Liver Diseases.
TLDR
Results showed that miR-138 can promote T-cell responses within patients with HBV infection by inducing a PD-1 blockade, which suggests that mi R-138 may serve as a new therapeutic target for the treatment ofHBV infection. Expand
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