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Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin.
- G. Schiavo, Q. Gu, G. Prestwich, T. Söllner, J. Rothman
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 12 November 1996
The synaptic vesicle membrane protein synaptotagmin (tagmin) is essential for fast, calcium-dependent, neurotransmitter release and is likely to be the calcium sensor for exocytosis, because of its… Expand
Probing the phosphoinositide 4,5-bisphosphate binding site of human profilin I.
- A. Chaudhary, J. Chen, Q. Gu, W. Witke, D. Kwiatkowski, G. Prestwich
- Medicine, Chemistry
- Chemistry & biology
- 1 May 1998
BACKGROUND Profilin is a widely and highly expressed 14 kDa protein that binds actin monomers, poly(L-proline) and polyphosphoinositol lipids. It participates in regulating actin-filament dynamics… Expand
Enzyme-Catalyzed Modifications of Polysaccharides and Poly(ethylene glycol)
Polysaccharides are used extensively in various industrial applications, such as food, adhesives, coatings, construction, paper, pharmaceuticals, and personal care. Many polysaccharide structures… Expand
Bioorganic Chemistry of Cyclic ADP-Ribose (CADPR)
[Studies on the antineoplastic action of N-methylisoindigotin].
- X. Ji, F. R. Zhang, Y. Liu, Q. Gu
- Chemistry, Medicine
- Yao xue xue bao = Acta pharmaceutica Sinica
- 1 April 1985
N-methylisoindigotin (Dian Ⅲ) is an analogue of indirubin. When given orally it exhibited significant inhibition against Lewis lung cancinoma and Walker carcinosarcoma 256. However, the effect of… Expand
A facile enzymatic resolution process for the preparation of (+)-S-2-(6-methoxy-2-naphthyl)propionic acid (naproxen)
Abstract (+)- S -2-(6-Methoxy-2-naphthyl)propionic acid ( 1 ) has been prepared via enzymatic enantlospecific hydrolysis of(±)-chloroethyl-2-(6-methoxy-2-naphthyl) propionate ( 3 ), catalyzed by the… Expand
Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs.
We tested for the presence of high-affinity phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and PI(3,4,5)P3 binding sites in four phospholipase C (PLC) isozymes (delta1, beta1, beta2, and beta3),… Expand
Enzymatic cyclization of nicotinamide adenine dinucleotide phosphate (NADP)
Abstract The ADP-ribosyl cyclase of Aplysia californica catalyzed the conversion of NADP, 3′-NADP and 2′,3′-cyclic NADP into their corresponding cyclic nucleotides (established by NMR, UV, and MS… Expand
Bioorganic chemistry of cyclic ADP-ribose (cADPR).
The objective of this brief review is to present an overview of the bioorganic chemistry of cyclic-ADP-ribose (cADPR) with special emphasis on the methodology used for the synthesis of analogues of… Expand
Cyclic ADP-Ribose: Synthesis and Structural Assignment