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Testicular hypofunction caused by activating p53 expression induced by reactive oxygen species in varicocele rats
TLDR
It is demonstrated that varicocele caused hypoxia that could cause the rise of ROS level to induce the increase of p53 expression, leading to the decrease of testis mass index and changes of seminiferous tubules, which would reduce sperm motility and result in male infertility eventually. Expand
MicroRNA-26 Was Decreased in Rat Cardiac Hypertrophy Model and May Be a Promising Therapeutic Target
TLDR
It is suggested that miR-26 regulates pathological structural changes in the rat heart, which may be associated with suppression of the GSK3&bgr; signaling pathway, and implicate the potential application of mi R-26 in diagnosis and therapy of cardiac hypertrophy. Expand
Effect of hepatocyte growth factor and angiotensin II on rat cardiomyocyte hypertrophy
TLDR
Treatment with 1 µM Ang II and 10 ng/mL HGF clearly induced a combined pro-hypertrophy effect on cardiomyocyte hypertrophy. Expand
Resveratrol ameliorates cardiac dysfunction induced by pressure overload in rats via structural protection and modulation of Ca2+ cycling proteins
TLDR
It is suggested that resveratrol may exert beneficial effects on cardiac hypertrophy through protection of cardiac structure and modulation of Ca2+ handling proteins and upregulation of Na+/Ca2+-exchangers and increased expression and phosphorylation of Ca 2+/calmodulin -dependent protein kinase II. Expand
Neuropeptide Y induces cardiomyocyte hypertrophy via calcineurin signaling in rats
TLDR
The result suggested that NPY could induce hypertrophy of cardiomyocytes via Ca2+/CaM-dependent CaN signal pathway, and the enhancement of [Ca2+]i caused by NPY may activate Ca N signal pathways to mediate cardiac hyperTrophy. Expand
Trimetazidine attenuates pressure overload-induced early cardiac energy dysfunction via regulation of neuropeptide Y system in a rat model of abdominal aortic constriction
TLDR
Cardiac metabolic remodeling is an early change in the myocardium before the presence of typical morphological ventricular remodeling following cardiac pressure overload, and pretreatment with TMZ may at least partly reverse the acute metabolic disturbance, perhaps via regulation of the NPY system. Expand
Alterations in cardiac structure and function in a modified rat model of myocardial hypertrophy
TLDR
It was concluded that this modified AAC model can develop LVH, both stably and safely, by week four post-surgery; echocardiography is able to assess changes in chamber dimensions and systolic properties accurately in rats with LVH. Expand
Changes in cardiac structure and function in a modified rat model of myocardial hypertrophy
TLDR
This modified AAC model induced LVH both stably and safely by week four post surgery, and echocardiography was accurately able to assess changes in chamber dimensions and systolic properties in the rats with LVH. Expand
[Role of CaN-NFATc3 pathway in abdominal aorta restenosis following ballon dilatation in rats].
TLDR
CaN-NFATc3 signal transduction pathway mediates restenosis of rat abdominal aorta following ballon dilatation, and CsA can attenuate the restenotic by suppressing this pathway. Expand