• Publications
  • Influence
Genetic basis and molecular mechanism for idiopathic ventricular fibrillation
Ventricular fibrillation causes more than 300, 000 sudden deaths each year in the USA alone,. In approximately 5–12% of these cases, there are no demonstrable cardiac or non-cardiac causes to accountExpand
  • 1,653
  • 49
The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds
Breast carcinoma is the most common malignancy among women in developed countries. Because family history remains the strongest single predictor of breast cancer risk, attention has focused on theExpand
  • 814
  • 23
  • PDF
KCNE1 mutations cause Jervell and Lange-Nielsen syndrome
  • 428
  • 21
Identification of an angiogenic factor that when mutated causes susceptibility to Klippel–Trenaunay syndrome
Angiogenic factors are critical to the initiation of angiogenesis and maintenance of the vascular network. Here we use human genetics as an approach to identify an angiogenic factor, VG5Q, andExpand
  • 250
  • 20
Mutation in Nuclear Pore Component NUP155 Leads to Atrial Fibrillation and Early Sudden Cardiac Death
Atrial fibrillation (AF) is the most common form of sustained clinical arrhythmia. We previously mapped an AF locus to chromosome 5p13 in an AF family with sudden death in early childhood. Here weExpand
  • 222
  • 9
Targeted Disruption of Fibulin-4 Abolishes Elastogenesis and Causes Perinatal Lethality in Mice
ABSTRACT Elastic fibers provide tissues with elasticity which is critical to the function of arteries, lungs, skin, and other dynamic organs. Loss of elasticity is a major contributing factor inExpand
  • 181
  • 6
Novel Roles of GATA1 in Regulation of Angiogenic Factor AGGF1 and Endothelial Cell Function*
AGGF1 is an angiogenic factor, and its deregulation is associated with a vascular malformation consistent with Klippel-Trenaunay syndrome (KTS). This study defines the molecular mechanism forExpand
  • 41
  • 6
Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.
Restless legs syndrome (RLS) is a common neurological disorder that affects 5%-12% of all whites. To genetically dissect this complex disease, we characterized 15 large and extended multiplexExpand
  • 194
  • 5
Association studies of variants in MEIS1, BTBD9, and MAP2K5/SKOR1 with restless legs syndrome in a US population.
BACKGROUND A genome-wide association study (GWAS) identified significant association between variants in MEIS1, BTBD9, and MAP2K5/SKOR1 and restless legs syndrome (RLS). However, many independentExpand
  • 55
  • 5
Identification of a New Co-factor, MOG1, Required for the Full Function of Cardiac Sodium Channel Nav1.5*
  • L. Wu, S. Yong, +11 authors Q. Wang
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 14 March 2008
The cardiac sodium channel Nav1.5 is essential for the physiological function of the heart and contributes to lethal cardiac arrhythmias and sudden death when mutated. Here, we report that MOG1, aExpand
  • 74
  • 4