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The M-superfamily with the typical Cys framework (-CC-C-C-CC-) is one of the seven major superfamilies of conotoxins found in the venom of cone snails. Based on the number of residues in the last Cys loop (between C4 and C5), M-superfamily conotoxins can be provisionally categorized into four branches (M-1, M-2, M-3, M-4) [Corpuz GP, Jacobsen RB, Jimenez(More)
The effects of a new O-superfamily conotoxin SO3 on sodium and potassium currents were examined in cultured rat hippocampal neurons using the whole-cell patch clamp technique. SO3 caused a concentration-dependent, rapidly developing and reversible inhibition of sodium currents (I(Na)). The IC(50) value for the blockage of I(Na) was calculated to be 0.49 and(More)
Events are crammed with numerous basic elements in today’s management and manufacturing system. Especially, for a large-scale system, there are thousands of independent messages (events) happening every second. How to integrate the information and how to deal with such massive events are faced by most of the system. Event monitoring and processing has been(More)
As the increasing use of RFID technology in manufacturing companies, the real-time production data collection is inadequate. Companies especially small and medium-sized manufacturing entities, contemplate to implement advanced planning and scheduling (APS) so as to achieve real-time production. This paper, motivated by a reallife case, proposes a real-time(More)
A series of novel 1,4-disubstituted piperidine/piperazine derivatives were designed, synthesized and evaluated for their in vitro activities against HIV-1 Bal (R5) infection in CEMX174 5.25M7 cells. A majority of these compounds showed potent anti-HIV-1 activities with IC(50) at nanomolar levels. N-(4-Fluoro-benzyl)piperazine analog B07 hydrochloride(More)