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Saccharum spontaneum is the most variable wild relative of sugarcane with potential for use in sugarcane improvement programs. In order to help preserve and exploit this species, 152 accessions from eight major geographical regions in China, including Hainan, Guangdong, Guangxi, Yunnan, Sichuan, Guizhou, Fujian, and Jiangxi provinces, were investigated by(More)
OBJECTIVE This study investigated compensation for loss of the fumaryl-acetoacetate hydrolase gene (Fah) by gene therapy using the Sleeping Beauty transposon system (SBTS), in a hereditary tyrosinaemia type 1 (HT-1) mouse model (Fah-/-). METHODS Twenty Fah-/- study mice, five wild-type positive controls and five Fah-/- negative controls were included.(More)
OBJECTIVE To explore whether quninalizarin, an specific inhibitor of protein kinase CK2, could sensitize icotinib in EGFR-TKIs (epithelial growth factor receptor-tyrosine kinase inhibitor)-resistant cell lines and uncover the underlying mechanisms. METHODS MTT assay was performed to evaluate the inhibitory effect of quninalizarin, icotinib or the(More)
OBJECTIVE To study the chemical constituents of Lagopsis supina. METHOD Compounds were separated by solvent extraction, column chromatography and TLC, and the structures were determined by chemical and spectral analyses. RESULTS Six compounds were isolated from the ethanol extract of L. supina and identified as eicosanoic acid octadecyl ester,(More)
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