Q. Huo

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This paper presents a new feature compensation approach to noisy speech recognition by using high-order vector Taylor series (HOVTS) approximation of an explicit model of environmental distortions. Formulations for maximum likelihood (ML) estimation of noise model parameters and minimum mean-squared error (MMSE) estimation of clean speech are derived.(More)
—In this paper, we present a formulation of minimum classification error linear regression (MCELR) for the adaptation of Gaussian mixture continuous-density hidden Markov model (CDHMM) parameters. Two optimization approaches, namely generalized probabilistic descent (GPD) and Quickprop are studied and compared for the optimization of the MCELR objective(More)
Spinal Muscular Atrophy (SMA) is caused by deletions or mutations in the Survival Motor Neuron 1 (SMN1) gene. The second gene copy, SMN2, produces some, but not enough, functional SMN protein. SMN is essential to assemble small nuclear ribonucleoproteins (snRNPs) that form the spliceosome. However, it is not clear whether SMA is caused by defects in this(More)
Fragments of botulinum neurotoxin (BoNT) have been explored as potential targeting moieties and carriers of biomolecules into neurons, although with lower binding and translocation efficiency compared with intact proteins. This study exploits a detoxified recombinant form of full-length BoNT/B (BoTIM/B) fused with core streptavidin (CS-BoTIM/B) for(More)
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