Puthusserickal Abdulrahiman Hassan

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The objective of the present investigation was to evaluate ability of the novel self-assembled phospholipid- based cationic nanocarriers (LeciPlex) in improving the therapeutic efficacy of a poorly water-soluble natural polyphenolic agent, quercetin (QR), on oral administration. Quercetin loaded LeciPlex (QR-LeciPlex) were successfully fabricated using a(More)
Reactions of biological oxidizing agents, such as hydroxyl radicals ((*)OH), singlet oxygen ((1)O(2)), hydrogen peroxide (H(2)O(2)), and peroxynitrite (ONOO(-)) with selenourea were studied. The kinetics of the reactions was followed using time-resolved techniques, and the bimolecular rate constants were determined. In all these reactions, under aerated(More)
The objective of the present investigation is to develop and characterize anionic mixed micelles of two biocompatible surfactants, Tween 80 (T-80) and sodium deoxycholate (NaDC), and evaluate their potential in the delivery of doxorubicin hydrochloride (DOX), a cationic anticancer drug. The mixed micelles were characterized for their microstructure,(More)
Dynamic light scattering (DLS) has evolved as a fast, convenient tool for particle size analysis of noninteracting spherical colloids. In this historical review, we discuss the basic principle, data analysis, and important precautions to be taken while analyzing colloids using DLS. The effect of particle interaction, polydispersity, anisotropy, light(More)
UNLABELLED Abstract Background: Ionizing radiation induces a plethora of DNA damage including double-strand breaks (DSB) that may trigger a series of events such as transcription, DNA repair and alteration in the conformation of chromatin structure in human cells. We have made an attempt to study the conformational changes in chromatin fibers in irradiated(More)
Natural fatty acids such as sodium oleate form highly viscous supramolecular complexes with long-chain cationic surfactants through cooperative self-assembly. Here we report the rheological behavior of linear and branched wormlike micelles formed in mixtures of cetyltrimethylammonium bromide (CTAB) and sodium oleate (NaOL). Addition of sodium oleate induces(More)
The aims of the present study were to formulate stable onion phases of the biodegradable surfactant PEG-8 Distearate (PEG8DS) and evaluate application of the onion phases in encapsulating sumatriptan succinate, a BCS class III potent antimigraine drug. Drug loaded and placebo onion phases were prepared by shearing lyotropic lamellar phases of the(More)
Controlling the morphological characteristics of micellar solutions is important for surfactant performance and for achieving desired properties. In this work we study how monovalent anions of the lyotropic series affect micellization, micellar transitions, and micellar growth of the cationic surfactant N-cetyl pyridinium chloride (CPyCl), with the aim of(More)
The addition of low concentrations of the hydrotropic salt p-toluidine hydrochloride (PTHC) to solutions of the anionic surfactant sodium dodecyl sulfate (SDS) promotes the transition from spherical to rodlike micelles. NMR measurements confirm that the hydrotrope adsorbs at the micelle-water interface, thereby screening electrostatic repulsions between the(More)
The electric field correlation function of light scattered from a polydispersed population of spherical particles having log-normal distribution with varying polydispersity is simulated. The correlation function with different polydispersity is compared with the method of cumulants over a wide range of correlation time. The large positive deviation of the(More)