Pushpinder Ferris

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Diploid cells of Chlamydomonas reinhardtii that are heterozygous at the mating-type locus (mt+/mt-) differentiate as minus gametes, a phenomenon known as minus dominance. We report the cloning and characterization of a gene that is necessary and sufficient to exert this minus dominance over the plus differentiation program. The gene, called mid, is located(More)
The mating-type locus of Chlamydomonas reinhardtii exists as two apparent alleles (mt+ and mt-) that control mating in haploid gametes and sporulation and meiosis in diploid mt+/mt- zygotes. Twelve genes, seven unrelated to life cycle transitions, are tightly linked to mt, suggesting that the locus exerts recombinational suppression. A 1.1 Mb chromosome(More)
A characteristic feature of early zygote development in Chlamydomonas is the selective degradation of chloroplast DNA from the mating type minus parent. The zygote-specific gene cluster ezy-1 is linked to the mating type locus and is transcribed almost immediately upon zygote formation. We show here that the acidic Ezy-1 polypeptide is rapidly transported(More)
There is increasing evidence that compounds with selectivity for gamma-aminobutyric acid(A) (GABA(A)) alpha2- and/or alpha3-subtypes may retain the desirable anxiolytic activity of nonselective benzodiazepines but possess an improved side effect profile. Herein we describe a novel series of GABA(A) alpha2/alpha3 subtype-selective agonists leading to the(More)
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