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A distributed Lagrange multiplier/fictitious domain method (DLM) is developed for simulating the motion of rigid particles suspended in the Oldroyd-B fluid. This method is a generalization of the one described in [1] where the motion of particles suspended in a Newtonian fluid was simulated. In our implementation of the DLM method, the fluid-particle system(More)
Leprosy was endemic in Europe until the Middle Ages. Using DNA array capture, we have obtained genome sequences of Mycobacterium leprae from skeletons of five medieval leprosy cases from the United Kingdom, Sweden, and Denmark. In one case, the DNA was so well preserved that full de novo assembly of the ancient bacterial genome could be achieved through(More)
Ubiquitous availability of cellular network and cheap mobile phones have made them promising sensing platforms for various application domains including healthcare, environment, and astronomy among others. However, existing mobile phone platforms, including even smartphones, provide limited in-built sensing capabilities and lack standard interfaces to(More)
The role played by overexpression of tyrosine kinase epidermal growth factor receptor (EGFR), the transmembrane receptor central to numerous cellular processes comprising cell migration, adhesion, apoptosis, and cell proliferation, has been highlighted in various cancers such as prostate, breast, lung, and ovarian cancers as well as in mutations in the EGFR(More)
Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained by conventional methods (6x coverage), and Illumina resequencing technology was used to obtain the(More)
The archaic centralized software systems, currently used to manage buildings, make it hard to incorporate advances in sensing technology and user-level applications, and present hurdles for experimental validation of open research in building information technology. Motivated by this, we --- a transnational collaboration of researchers engaged in(More)
The cell cycle is a ubiquitous, multi-step process that is essential for growth and proliferation of cells. The role of membrane lipids in cell cycle regulation is not explored well, although a large number of cytoplasmic and nuclear regulators have been identified. We focus in this work on the role of membrane cholesterol in cell cycle regulation. In(More)
Suppression of T cell response is thought to be involved in the pathogenesis of visceral leishmaniasis (VL). Regulatory T cell (Treg) mediated immune-suppression is reported in animal models of Leishmania infection. However, their precise role among human patients still requires pathologic validation. The present study is aimed at understanding the(More)
A major problem in developing ubiquitous computing applications is the simulation of the required infrastructure and the environment in which they are to be deployed. Developers have to rely on either low-fidelity techniques (such as paper prototypes and mental walk-throughs) or simply wait for a full scale deployment. Similarly, even where an existing(More)