Purvi Y Patel

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BACKGROUND Preoperative risk assessment is important yet inexact in older patients because physiologic reserves are difficult to measure. Frailty is thought to estimate physiologic reserves, although its use has not been evaluated in surgical patients. We designed a study to determine if frailty predicts surgical complications and enhances current(More)
Induced elevations in intracellular cAMP caused remarkable shape changes in cultured mesangial cells that were prevented by prostaglandin E2 (PGE2). The purpose of this study was to determine the morphological and physiological basis for these alterations. Coincident with elevated levels of cAMP and shape change there was rapid dissolution of stress fibers.(More)
OBJECTIVE To review the literature and summarize the available evidence about the relationship of fibroids with infertility and to review the role of laparoscopic myomectomy in infertility. MATERIALS AND METHODS Medline, PubMed, and Cochrane Databases were searched for articles published between 1980 and 2010. RESULTS Fertility outcomes are decreased in(More)
The mesangial cell is a glomerular cell type with smooth muscle-like (contractile) properties. The responses evoked in cultured mesangial cells by catecholamines were examined in the presence or absence of prostaglandin E2 (PGE2) with or without a phosphodiesterase inhibitor. Exposure to 10(-4) M norepinephrine, epinephrine, or isoproterenol elevated(More)
Glomeruli isolated from streptozotocin-diabetic rats produced significantly greater amounts of immunoreactive prostaglandin (PG)E2, PGF2 alpha, and prostacyclin (PGI2) measured as the stable metabolite 6-keto-PGF1 alpha than control glomeruli. These data led to studies to determine whether the vasoactive glomerular mesangial cell exhibited alterations in(More)
Various studies have demonstrated that during pregnancy, the whole blood and plasma selenium concentrations, and the activity of glutathione peroxidase in red cells and plasma decline in a linear fashion from the first trimester to parturition, with the lowest levels at delivery 2. It has also been demonstrated that the requirement of selenium is increased(More)
Cultured glomerular epithelial cells form a continuous monolayer of polyhedral-shaped cells. PGE2 (1 μg/ml) in the presence of the phosphodiesterase inhibitor isobutylmethylxanthine (MIX) markedly raises intracellular and medium cyclic AMP (cAMP) levels at 20 min (intracellular: MIX alone, 112 ± 6.6 pmol cAMP/mg protein, MIX plus PGE2, 2252±63 pmol cAMP/mg(More)
BACKGROUND: Preoperative risk assessment is important yet inexact in older patients because physiologic reserves are difficult to measure. Frailty is thought to estimate physiologic reserves, although its use has not been evaluated in surgical patients. We designed a study to determine if frailty predicts surgical complications and enhances current(More)
AIM To assess the safety of labor epidural analgesia in subjects with pre-eclampsia. METHODS Nulliparous laboring women were included in the prospective study. One hundred pre-eclamptic nullipara who were given epidural analgesia (group I) were compared with 100 nullipara with pre-eclampsia who were not given epidural analgesia (group II). The outcome was(More)
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