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STUDY DESIGN A new recombinant adenoviral vector expressing Sox9, a chondrocyte-specific transcription factor, was tested in a chondroblastic cell line and primary human intervertebral disc cells in vitro. Direct infection of intervertebral disc cells then was assessed in a rabbit model. OBJECTIVES To deliver a potentially therapeutic viral vector(More)
BACKGROUND CONTEXT Recurrent low back pain (LBP) is a common and costly problem that might be related to increased spine loads in those with LBP. However, we know little about how the spine is loaded when those with LBP perform lifting exertions. PURPOSE Document spine loading patterns of patients with LBP performing symmetric and asymmetric lifting(More)
BACKGROUND CONTEXT Dynamic anterior plates have been popularized to promote cervical spine fusion by allowing controlled settling, thereby promoting load sharing across the construct. To date these proposed benefits have been largely theoretical and there are no studies confirming any benefits over more traditional static plates. PURPOSE To compare the(More)
STUDY DESIGN The impact of various levels of mental processing and pacing (during lifting) on spine loading was monitored under laboratory conditions. OBJECTIVES To explore how mental demands and pacing influence the biomechanical response and subsequent spine loading and, to determine whether individual characteristics have a modifying role in the(More)
STUDY DESIGN Spine loadings during a variety of lifting exertions were compared with individual torso kinematic abilities. Relationships were evaluated between these measures. OBJECTIVE To determine if trunk kinematic status (functional impairment) is indicative of spine loading increases in patients with low back pain (LBP) compared to asymptomatic(More)
STUDY DESIGN Repeated measures study design. OBJECTIVE Determine a meaningful change in low back functional impairment as measured with the lumbar motion monitor. SUMMARY OF BACKGROUND DATA A quantitative functional performance probability (P(n)) measure has been developed and is scored from 0.00 to 1.00. Previous research has shown that a 0.5 cut-off(More)
BACKGROUND Low back disorders are a prevalent problem in society today and may lead to chronic debilitating low back pain. Developing our understanding of temporal muscle and kinematic patterns during manual material handling tasks may provide insight for preventing the cascading series of events leading to chronic low back pain. METHODS Sixty-two low(More)
BACKGROUND CONTEXT Accurate anatomical inputs for biomechanical models are necessary for valid estimates of internal loading. The magnitude of the moment arm of the lumbar erector muscle group is known to vary as a function of such variables as gender. Anatomical evidence indicates that the moment arms decrease during torso flexion. However, moment arm(More)
STUDY DESIGN Prospective. OBJECTIVES The goals of this study were to (1) evaluate the differences in weightbearing symmetry between individuals with adolescent idiopathic scoliosis (AIS) and typically developing controls; (2) observe the effect of posterior spinal fusion and instrumentation (PSFI) on volitional weight-shifting at 1 and 2 years(More)
STUDY DESIGN Prospective. OBJECTIVES The goal of this study was to evaluate the effect of posterior spinal fusion surgery terminating at different lowest instrumented vertebrae (LIV) on trunk mobility in individuals with adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA Posterior spinal fusion with instrumentation is the standard(More)