Purnendu Gupta

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STUDY DESIGN A new recombinant adenoviral vector expressing Sox9, a chondrocyte-specific transcription factor, was tested in a chondroblastic cell line and primary human intervertebral disc cells in vitro. Direct infection of intervertebral disc cells then was assessed in a rabbit model. OBJECTIVES To deliver a potentially therapeutic viral vector(More)
STUDY DESIGN The impact of various levels of mental processing and pacing (during lifting) on spine loading was monitored under laboratory conditions. OBJECTIVES To explore how mental demands and pacing influence the biomechanical response and subsequent spine loading and, to determine whether individual characteristics have a modifying role in the(More)
BACKGROUND Low back disorders are a prevalent problem in society today and may lead to chronic debilitating low back pain. Developing our understanding of temporal muscle and kinematic patterns during manual material handling tasks may provide insight for preventing the cascading series of events leading to chronic low back pain. METHODS Sixty-two low(More)
OBJECTIVE Quantification of the maximum anatomical cross-sectional area of the lumbar back muscles as a function of torso flexion angle and development of prediction equations as a function of torso flexion and anthropometric measures. BACKGROUND Cross-sectional areas of the lumbar back muscles used as inputs into biomechanical models have traditionally(More)
BACKGROUND CONTEXT Accurate anatomical inputs for biomechanical models are necessary for valid estimates of internal loading. The magnitude of the moment arm of the lumbar erector muscle group is known to vary as a function of such variables as gender. Anatomical evidence indicates that the moment arms decrease during torso flexion. However, moment arm(More)
STUDY DESIGN Spine loadings during a variety of lifting exertions were compared with individual torso kinematic abilities. Relationships were evaluated between these measures. OBJECTIVE To determine if trunk kinematic status (functional impairment) is indicative of spine loading increases in patients with low back pain (LBP) compared to asymptomatic(More)
Tofacitinib (CP-690,550) is a novel, oral Janus kinase inhibi-tor that is currently being investigated as a targeted immuno-modulator for the treatment of several autoimmune diseases such as psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, and dry eye disease, and for prophylaxis of renal transplant(More)
This paper presents a new, compelling argument for a larger potential to reduce labor cost by adopting cloud computing in enterprise IT. The additional cost reduction is possible in the labor intensive activities of customer-specific customization of cloud services, tools support, and customer-facing service management. These essential service delivery(More)
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