Purnendu Gupta

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BACKGROUND CONTEXT Dynamic anterior plates have been popularized to promote cervical spine fusion by allowing controlled settling, thereby promoting load sharing across the construct. To date these proposed benefits have been largely theoretical and there are no studies confirming any benefits over more traditional static plates. PURPOSE To compare the(More)
STUDY DESIGN Trunk angular motion features were used as a means to quantify the extent of a low back disorder in healthy people and patients with chronic low back disorders. OBJECTIVE To refine and validate a previously reported means of quantifying the extent of a low back disorder. SUMMARY AND BACKGROUND Many assessment tools of low back disorder are(More)
STUDY DESIGN Repeated measures study design. OBJECTIVE Determine a meaningful change in low back functional impairment as measured with the lumbar motion monitor. SUMMARY OF BACKGROUND DATA A quantitative functional performance probability (P(n)) measure has been developed and is scored from 0.00 to 1.00. Previous research has shown that a 0.5 cut-off(More)
STUDY DESIGN A new recombinant adenoviral vector expressing Sox9, a chondrocyte-specific transcription factor, was tested in a chondroblastic cell line and primary human intervertebral disc cells in vitro. Direct infection of intervertebral disc cells then was assessed in a rabbit model. OBJECTIVES To deliver a potentially therapeutic viral vector(More)
STUDY DESIGN Patients with low back pain and asymptomatic individuals were evaluated while performing controlled and free-dynamic lifting tasks in a laboratory setting. OBJECTIVE To evaluate how low back pain influences spine loading during lifting tasks. SUMMARY OF BACKGROUND DATA An important, yet unresolved, issue associated with low back pain is(More)
BACKGROUND Low back disorders are a prevalent problem in society today and may lead to chronic debilitating low back pain. Developing our understanding of temporal muscle and kinematic patterns during manual material handling tasks may provide insight for preventing the cascading series of events leading to chronic low back pain. METHODS Sixty-two low(More)
OBJECTIVE Quantification of the maximum anatomical cross-sectional area of the lumbar back muscles as a function of torso flexion angle and development of prediction equations as a function of torso flexion and anthropometric measures. BACKGROUND Cross-sectional areas of the lumbar back muscles used as inputs into biomechanical models have traditionally(More)
STUDY DESIGN The impact of various levels of mental processing and pacing (during lifting) on spine loading was monitored under laboratory conditions. OBJECTIVES To explore how mental demands and pacing influence the biomechanical response and subsequent spine loading and, to determine whether individual characteristics have a modifying role in the(More)
The different alleles of the apolipoprotein E gene (APOE-gene, ApoE-protein) have been reported to influence recovery after traumatic brain injury (TBI) in both human patients and animal models, with the e4 allele typically conferring poorer prognosis for recovery. How the E4 allele, and consequently the ApoE4 isoform, affects recovery is unknown, but(More)
Individuals who have low back pain (LBP) have significantly different motion characteristics than healthy individuals. However, the cause of these differences is unknown. Oxygen use of the erector spinae muscle was examined while simultaneously monitoring motion characteristics to determine whether oxygen use differed between healthy and LBP individuals.(More)