Pureun-Haneul Lee

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PURPOSE Diesel exhaust particles (DEPs) can induce and trigger airway hyperresponsiveness (AHR) and inflammation. The aim of this study was to investigate the effect of long-term DEP exposure on AHR, inflammation, lung fibrosis, and goblet cell hyperplasia in a mouse model. METHODS BALB/c mice were exposed to DEPs 1 hour a day for 5 days a week for 3(More)
BACKGROUND Angiopoietin-1 (Ang-1) is an essential mediator of angiogenesis that establishes vascular integrity, and angiopoietin-2 (Ang-2) acts as its natural inhibitor. We considered that angiopoietin might be important in bronchial asthma. METHODS In total, 35 patients with asthma and 20 healthy subjects were studied. RESULTS The serum Ang-1 levels(More)
BACKGROUND Angiopoietin (Ang)-1 and -2 are involved in the pathogenesis of asthma and have been identified as markers of asthma severity. OBJECTIVE To determine the relation between circulating angiopoietins and clinical variables of patients with asthma. METHODS Fifty patients with bronchial asthma and 25 healthy controls were enrolled. Ang1 and Ang2(More)
PURPOSE Nanoparticles (NPs) may cause cell and tissue damage, leading to local and systemic inflammatory responses and adverse effects on health due to the inhalation of particulate matter. The inflammasome is a major regulator of inflammation through its activation of pro-caspase-1, which cleaves pro-interleukin-1β (pro-IL-1β) into its mature form and may(More)
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