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We present the design of Espresso, Google's SDN-based Internet peering edge routing infrastructure. This architecture grew out of a need to exponentially scale the Internet edge cost-effectively and to enable application-aware routing at Internet-peering scale. Espresso utilizes commodity switches and host-based routing/packet processing to implement a(More)
BACKGROUND BK viremia can lead to nephritis, which can progress to irreversible kidney transplant failure. Our prospective study provides management and outcome of BK viremia in renal transplant recipients. METHODS Two hundred forty de novo kidney-only recipients were enrolled from July 2007 to July 2010 and followed for 1 year. Standard immunosuppression(More)
Patients with end-stage liver disease awaiting liver transplantation frequently require intensive care admission and management due to either complications of liver failure or to intercurrent illness, particularly infection. Mortality in such patients is high and the development of an illness necessitating intensive care unit management can influence(More)
BACKGROUND Previously, we reported that the prophylactic use of nesiritide did not reduce the incidence of dialysis or death following cardiovascular (CV) surgery despite reducing the incidence of acute kidney injury (AKI) in the immediate postoperative period. Therefore, we investigated whether the observed renal benefits of nesiritide had any long-term(More)
BACKGROUND Hospital admissions over weekends have been associated with worse outcomes in different patient populations. The cause of this difference in outcomes remains unclear; however, different staffing patterns over weekends have been speculated to contribute. We evaluated outcomes in patients on maintenance dialysis therapy admitted over weekends using(More)
Desensitization therapy enables HLA-incompatible transplantation. However, desensitized patients have an increased risk of antibody-mediated rejection, and the presence of donor-specific antibodies (DSAs) is associated with poor outcomes. A new study has assessed the effect of rituximab induction on DSA production in kidney transplant recipients with high(More)
Histologic analysis of the allograft biopsy specimen is the standard method used to differentiate rejection from other injury in kidney transplants. Donor-derived cell-free DNA (dd-cfDNA) is a noninvasive test of allograft injury that may enable more frequent, quantitative, and safer assessment of allograft rejection and injury status. To investigate this(More)
Case Based Reasoning (CBR) has become a successful methodology for problem solving, reasoning and learning. It is applied for diagnosis and decision support in the medical field in several areas. This is because CBR methodology is analogous to the process of human reasoning and natural problem solving. In this paper, a Swine Flu Medical Recommender (SFMR)(More)
Case Based Reasoning (CBR) has become a successful methodology for problem solving, reasoning and learning. It is applied for diagnosis and decision support in the medical field in several areas. This is because CBR methodology is analogous to the process of human reasoning and natural problem solving. In this paper, a CBR aided Swine Flu Diagnostic(More)