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In this study, we report on a virtual ligand screening protocol optimized to identify fragments endowed with activity at multiple targets. Thanks to this protocol, we were able to identify a fragment that displays activity in the low-micromolar range at both β-secretase 1 (BACE-1) and glycogen synthase kinase 3β (GSK-3β). These two structurally and(More)
The ability of the BACE-1 catalytic dyad to adopt multiple protonation states and the conformational flexibility of the active site have hampered the reliability of computational screening campaigns carried out on this drug target for Alzheimer's disease. Here, we propose a protocol that, for the first time, combining quantum mechanical calculations,(More)
  • P P Kacker
  • 1973
A 17-year-old, single, woman born in the United Kingdom attended on June 26, 1971, complaining of vaginal discharge and vulval soreness of 2 months' duration. There was no history of dysuria or of recent antibiotic treatment and she was not taking contraceptive pills. She had a British boy friend with whom she had regular intercourse; he was said to have no(More)
An open, randomized general practice study was performed to assess the comparative efficacy and tolerability of ciprofloxacin and amoxycillin/clavulanic acid in the treatment of uncomplicated urinary tract infection. One hundred and eighty nine patients were recruited into the study. In comparison of pre- and post-treatment urine cultures and(More)
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