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- Publications
- Influence
Ubc9 sumoylation regulates SUMO target discrimination.
- Puck Knipscheer, Annette Flotho, +7 authors A. Pichler
- Biology, Medicine
- Molecular cell
- 8 August 2008
Posttranslational modification with small ubiquitin-related modifier, SUMO, is a widespread mechanism for rapid and reversible changes in protein function. Considering the large number of known… Expand
SUMO modification of the ubiquitin-conjugating enzyme E2-25K
- A. Pichler, Puck Knipscheer, +6 authors T. Sixma
- Chemistry, Medicine
- Nature Structural &Molecular Biology
- 20 February 2005
Post-translational modification with small ubiquitin-related modifier (SUMO) alters the function of many proteins, but the molecular mechanisms and consequences of this modification are still poorly… Expand
Vasohibins encode tubulin detyrosinating activity
- Joppe Nieuwenhuis, Athanassios Adamopoulos, +8 authors T. Brummelkamp
- Biology, Medicine
- Science
- 15 December 2017
Tubulin carboxypeptidase identity revealed Enzymes of the α-tubulin detyrosination/tyrosination cycle create landmarks on microtubules that are essential for their multiple cellular functions and are… Expand
HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
- I. Brandsma, K. Sato, +17 authors A. Zelensky
- Biology, Medicine
- Cell reports
- 25 June 2019
The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability, and DNA interstrand crosslink repair in vertebrates. We identify HSF2BP, a protein previously… Expand
SUMO assay with peptide arrays on solid support: insights into SUMO target sites.
- K. Schwamborn, Puck Knipscheer, +4 authors J. Langedijk
- Biology, Medicine
- Journal of biochemistry
- 1 July 2008
The modification of proteins by SUMO (small ubiquitin-like modifier) regulates various cellular processes. Sumoylation often occurs on a specific lysine residue within the consensus motif psiKxE/D.… Expand
Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms
- Michael R G Hodskinson, Alice Bolner, +11 authors Puck Knipscheer
- Chemistry, Medicine
- Nature
- 1 March 2020
Acetaldehyde is a highly reactive, DNA-damaging metabolite that is produced upon alcohol consumption 1 . Impaired detoxification of acetaldehyde is common in the Asian population, and is associated… Expand
Crystal structure of SUMO modified ubiquitin conjugating enzyme E2- 25K
- A. Pichler, Puck Knipscheer, +6 authors T. Sixma
- Chemistry
- 16 February 2005
HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair
- K. Sato, I. Brandsma, +7 authors A. Zelensky
- Biology, Medicine
- Nucleic acids research
- 21 January 2020
Abstract The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability and DNA interstrand crosslink (ICL) repair in vertebrates. We show that ectopic… Expand
Analysis of E2 sumoylation in Saccharomyces cerevisiae
- H. Klug, Puck Knipscheer, +5 authors A. Pichler
- Chemistry
- 1 July 2007
Multistep mechanism of DNA replication-coupled G-quadruplex resolution
- K. Sato, Nerea Martin-Pintado, Harm Post, M. Altelaar, Puck Knipscheer
- Chemistry, Biology
- 11 November 2020
G-quadruplex (or G4) structures are non-canonical DNA structures that form in guanine-rich sequences and threaten genome stability when not properly resolved. G4 unwinding occurs during S phase via… Expand
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