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Ubc9 sumoylation regulates SUMO target discrimination.
Posttranslational modification with small ubiquitin-related modifier, SUMO, is a widespread mechanism for rapid and reversible changes in protein function. Considering the large number of knownExpand
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SUMO modification of the ubiquitin-conjugating enzyme E2-25K
Post-translational modification with small ubiquitin-related modifier (SUMO) alters the function of many proteins, but the molecular mechanisms and consequences of this modification are still poorlyExpand
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Vasohibins encode tubulin detyrosinating activity
Tubulin carboxypeptidase identity revealed Enzymes of the α-tubulin detyrosination/tyrosination cycle create landmarks on microtubules that are essential for their multiple cellular functions and areExpand
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HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability, and DNA interstrand crosslink repair in vertebrates. We identify HSF2BP, a protein previouslyExpand
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SUMO assay with peptide arrays on solid support: insights into SUMO target sites.
The modification of proteins by SUMO (small ubiquitin-like modifier) regulates various cellular processes. Sumoylation often occurs on a specific lysine residue within the consensus motif psiKxE/D.Expand
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Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms
Acetaldehyde is a highly reactive, DNA-damaging metabolite that is produced upon alcohol consumption 1 . Impaired detoxification of acetaldehyde is common in the Asian population, and is associatedExpand
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HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair
Abstract The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability and DNA interstrand crosslink (ICL) repair in vertebrates. We show that ectopicExpand
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Analysis of E2 sumoylation in Saccharomyces cerevisiae
Multistep mechanism of DNA replication-coupled G-quadruplex resolution
G-quadruplex (or G4) structures are non-canonical DNA structures that form in guanine-rich sequences and threaten genome stability when not properly resolved. G4 unwinding occurs during S phase viaExpand
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