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Rapid Determination of Antimicrobial Susceptibility by Stimulated Raman Scattering Imaging of D2O Metabolic Incorporation in a Single Bacterium
Abstract Rapid antimicrobial susceptibility testing (AST) is urgently needed for treating infections with appropriate antibiotics and slowing down the emergence of antibiotic‐resistant bacteria.… Expand
Label-Free Imaging of Heme Dynamics in Living Organisms by Transient Absorption Microscopy.
- A. J. Chen, X. Yuan, J. Li, Pu-Ting Dong, I. Hamza, Ji-Xin Cheng
- Chemistry, Medicine
- Analytical chemistry
- 5 February 2018
Heme, a hydrophobic and cytotoxic macrocycle, is an essential cofactor in a large number of proteins and is important for cell signaling. This must mean that heme is mobilized from its place of… Expand
Photolysis of Staphyloxanthin in Methicillin‐Resistant Staphylococcus aureus Potentiates Killing by Reactive Oxygen Species
Abstract Confronted with the severe situation that the pace of resistance acquisition is faster than the clinical introduction of new antibiotics, health organizations are calling for effective… Expand
Label-free quantitation of glycated hemoglobin in single red blood cells by transient absorption microscopy and phasor analysis
Transient absorption microscopy could detect HbA1c, which is a stable biomarker for diabetes, at single–red blood cell level. As a stable and accurate biomarker, glycated hemoglobin (HbA1c) is… Expand
Quantitative imaging of intraerythrocytic hemozoin by transient absorption microscopy
- Andy Chen, Kai-Chih Huang, +6 authors Ji-Xin Cheng
- Chemistry, Engineering
- Journal of biomedical optics
- 1 December 2019
Abstract. Hemozoin, the heme detoxification end product in malaria parasites during their growth in the red blood cells (RBCs), serves as an important marker for diagnosis and treatment target of… Expand
Quinine Enhances Photo-Inactivation of Gram-Negative Bacteria.
- Leon G Leanse, Pu-Ting Dong, +4 authors T. Dai
- Chemistry, Medicine
- The Journal of infectious diseases
- 3 February 2020
Antimicrobial resistance is a significant concern to public health, and there is a pressing need to develop novel antimicrobial therapeutic modalities. In this study, we investigated the capacity for… Expand
Photo-Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA
Confronted with the rapid evolution and dissemination of antibiotic resistance, there is an urgent need to develop alternative treatment strategies for drug-resistant pathogens. Here, we present an… Expand
Photo‐Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA
Abstract Confronted with the rapid evolution and dissemination of antibiotic resistance, there is an urgent need to develop alternative treatment strategies for drug‐resistant pathogens. Here, an… Expand
Annihilation of Methicillin-resistant Staphylococcus aureus via Photobleaching of Staphyloxanthin
Given that the dearth of new antibiotic development loads an existential burden on successful infectious disease therapy1, health organizations are calling for alternative approaches to combat… Expand
Staphyloxanthin Photolysis Potentiates Low Concentration Silver Nanoparticles in Eradication of Methicillin-Resistant Staphylococcus aureus
The rise of antibiotic resistant bacteria, e.g., methicillin-resistant Staphylococcus aureus (MRSA), has resulted in a widespread search for alternative treatments not reliant on traditional antibi...