Pu Shi

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Cytotoxicity, low water solubility, rapid clearance from circulation, and off-target side-effects are common drawbacks of conventional small-molecule drugs. To overcome these shortcomings, many multifunctional nanocarriers have been proposed to enhance drug delivery. In concept, multifunctional nanoparticles might carry multiple agents, control release(More)
We study the problem of anonymizing data with quasi-sensitive attributes. Quasi-sensitive attributes are not sensitive by themselves, but certain values or their combinations may be linked to external knowledge to reveal indirect sensitive information of an individual. We formalize the notion of <i>l-diversity</i> and <i>t-closeness</i> for quasi-sensitive(More)
B-cell lymphomas continue to occur with a high incidence. The chimeric antibody known as Rituximab (Rituxan) has become a vital therapy for these patients. Rituximab induces cell death via binding and clustering of the CD20 receptor by Fcγ expressing effector cells. Because of the limited mobility of effector cells, it may be advantageous to cluster CD20(More)
Dajiang is a traditional fermented food prepared from soybeans that is still popular in northeast China. Although recent studies have revealed that a variety of bacterial species contribute to the production of fermented soybean products, little is known about bacterial communities involved in the fermentation of dajiang made in northeast China. In this(More)
In this paper we study the problem of anonymizing data with quasi-sensitive attributes values. By quasi-sensitive attributes, we mean those attributes that are not sensitive by themselves, but certain values or their combinations may be linked to external knowledge to reveal indirect sensitive information of an individual. Most existing work are focused on(More)
Artemisinin is a frequently used anti-malaria drug extracted from glandular trichomes (GSTs) in Artemisia annua L. In this study, we report on the characterization of the promoter of aldehyde dehydrogenase 1 (ALDH1) involved in the biosynthesis of artemisinin. A 1620-bp promoter fragment was cloned upstream of the ALDH1 start codon. Putative regulatory(More)
Artemisinin is an effective component of drugs against malaria. The regulation of artemisinin biosynthesis is at the forefront of artemisinin research. Previous studies showed that AaWRKY1 can regulate the expression of ADS, which is the first key enzyme in artemisinin biosynthetic pathway. In this study, AaWRKY1 was cloned, and it activated ADSpro and(More)