Przemysław Jacek Kotyla

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Dear Editor, We read with interest the paper by Serelis J. et al. “Effect of anti-TNF treatment on body composition and serum adiponectin levels of women with rheumatoid arthritis” [1]. This study gives a new insight into the influence of TNF alpha and its inhibition on fat tissue metabolism in patients with chronic inflammatory polyarthropaty—rheumatoid(More)
3-Hydroxy-3-Methyl-Glutharyl-Coenzyme A reduct- ase inhibitors, known as statins, form a group of chemical compounds that are characterized by the ability to inhibit cholesterol synthesis. Statins have proved their efficacy as potent drugs in the primary and secondary prevention of cardiovascular events. It has also been shown that the thera- peutic effects(More)
Systemic lupus erythematosus is a connective tissue disease of unknown origin and unpredictable course. At the moment there is no specific targeted treatment for the disease and corticosteroids are still main therapeutic option. Steroid use, however brings many side effects. Therefore searching for new treatment strategies is at the moment the main(More)
Treatment targeting TNF revolutionized management for rheumatoid arthritis patients offering attainment of clinical remission, preventing patients from disability and improving their quality of life. Anti-cytokine therapy, however may in some circumstance contribute to development of serious adverse effects, including congestive heart failure. The heart(More)
INTRODUCTION Systemic lupus erythematosus (SLE) is a systemic inflammatory disease of connective tissue with an unknown etiology and a rich clinical picture with involvement of multiple organs. Given the rich symptomatology, application of the current classification criteria is associated with a significant risk of attributing symptoms of other pathologies(More)
This paper described newly discovered peptides, brain natriuretic peptide and C-type natriuretic peptide. Their structure and metabolism as well as peptides participation to many physiological and pathological states have been reviewed with a special emphasis to their role in blood pressure regulation and mineral and fluid balance.