Prudence Mutowo

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Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge of parasite biology. Here, we describe(More)
ChEMBL is an open large-scale bioactivity database (https://www.ebi.ac.uk/chembl), previously described in the 2012 and 2014 Nucleic Acids Research Database Issues. Since then, alongside the continued extraction of data from the medicinal chemistry literature, new sources of bioactivity data have also been added to the database. These include: deposited(More)
Modern day science attempts to conquer diseases by looking for small druggable target molecules whose interactions are implicated in disease states in the body. Through the years, drug discovery has evolved from a " magic bullet " concept (where a compound is used to target a particular biomolecule) to a search for molecules whose behaviour can be modified(More)
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