Prudence Mutowo

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BACKGROUND The process of discovering new drugs is a lengthy, time-consuming and expensive process. Modern day drug discovery relies heavily on the rapid identification of novel 'targets', usually proteins that can be modulated by small molecule drugs to cure or minimise the effects of a disease. Of the 20,000 proteins currently reported as comprising the(More)
ChEMBL is an open large-scale bioactivity database (https://www.ebi.ac.uk/chembl), previously described in the 2012 and 2014 Nucleic Acids Research Database Issues. Since then, alongside the continued extraction of data from the medicinal chemistry literature, new sources of bioactivity data have also been added to the database. These include: deposited(More)
Modern day science attempts to conquer diseases by looking for small druggable target molecules whose interactions are implicated in disease states in the body. Through the years, drug discovery has evolved from a " magic bullet " concept (where a compound is used to target a particular biomolecule) to a search for molecules whose behaviour can be modified(More)
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