Prof. Pier P. F. Mannaioni

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Despite the fact that the relationship between platelets and the inflammatory and immune responses has been reviewed previously, the allocation of platelets among the inflammatory cells is still at issue. Recent developments in our understanding of platelet-associated signalling events have offered new potential insights into platelet functions in(More)
Histamine has been proved to be released during myocardial infarction and ischemic arrhythmias in dogs. The aim of the present experiments was to evaluate if ischemia and reperfusion modify histamine and lactate dehydrogenase (LDH) release in isolated guinea-pig heart. The results obtained show a steady increase of LDH release both in the ischemic and(More)
Free radicals produced by the occlusion and opening of the left anterior descending coronary artery and/or by perfusion of isolated guinea-pig heart with FeCl3/ADP (10 μM/100 μM) induce a differential release of histamine and lactate dehydrogenase (LDH) in the perfusates with a preferential liberation of histamine in the reperfusion phase, associated with(More)
Histamine H3 receptors act as inhibitory autoand heteroreceptors, thus inhibiting histamine synthesis and release, as well as the release of other neurotransmitters, including ACh (for a review see [1]). Indeed, local administration of H3 receptors antagonists decreased ACh spontaneous release from the basolateral amygdala (BLA) of freely moving rats, and(More)
There is much evidence that interactions between cholinergic systems and several neurotransmitters, including norepinephrine, GABA and serotonin, may be important in learning and memory [1]. Histamine also plays a role in cognitive processes [2, 3], and the mechanism might depend on histaminergic-cholinergic interactions [4]. Indeed, activation of cortical(More)
The early diagnosis and evaluation of the biological consequences of alcohol abuse are reviewed in a population of 401 chronic alcoholics admitted to our Toxicological Unit from January 1973 to the end of December 1984; selected cases were treated with disulfiram implantation. The results of the study indicate that anemia with increased globular volume of(More)
A large number of studies indicate that increased levels of oxygen-derived free radicals produced by infl ammatory and epithelial cells in the airway are important mediators in the pathogenesis of asthma [1, 2]. Cannabinoids, reported to have antioxidant properties [3], are known to induce their biological effects by binding to specifi c cannabinoid(More)