Prof. Dr. Karl Heinz Rahn

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In blood many drugs are partly associated with blood constituents such as plasma proteins and erythrocytes. For most such drugs, only the unbound fraction of the total amount is available for diffusion out of the vascular system to sites of pharmacological activity. The unbound fraction of drug in plasma is therefore regarded as pharmacologically active,(More)
Hot-stage microscopy, thermoanalytical methods, and X-ray powder diffraction were used to demonstrate that crystalline erythromycin dihydrate converts to the crystalline anhydrate via a noncrystalline intermediate. X-ray powder diffraction, IR spectral, thermogravimetric, and differential thermal analyses were used to characterize the monohydrate material.(More)
The effects of the use of 60Co-irradiation to sterilize antibiotics were evaluated. The antibiotic powders were only occasionally contaminated with microorganisms. The D-values of the products and environmental isolates were 0.028, 0.027, 0.015, 0.046, 0.15, 0.018, and 0.19 Mrads for Aspergillus species (UC 7297, 7298), A. fumigatus (UC 7299), Rhodotorula(More)
Methods for the determination of flurbiprofen and ibuprofen in dog serum were developed using high-performance liquid chromatography and automated serum extraction. Sample extraction was automated by use of cartridges packed with a styrene-divinylbenzene macroreticular resin in a microprocessor-controlled centrifugal system. The average recoveries were(More)
There are now several antihypertensive agents with dual actions. Among these, labetalol has been studied most extensively. The drug has a place in the chronic treatment of hypertension and in the therapy of hypertensive emergencies. Carvedilol, now available in Germany, has been shown to be effective in different forms of hypertension. Celiprolol binds to(More)
Patienten mit Bluthochdruck werden in der Regel langfristig vom Hausarzt betreut. Die Therapie muss sich am individuellen Risiko sowie an möglichen Folge- und Begleiterkrankungen orientieren. Der wesentliche Nutzen der antihypertensiven Behandlung beruht dabei auf der Blutdrucksenkung an sich. Neben Allgemeinmaßnahmen steht eine Vielzahl von Medikamenten(More)
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