Prof. Dr. F. Z. Meerson

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A working hypothesis on pathogenesis of ischemic heart damage has been proposed. According to this hypothesis, a crucial role in conversion of reversible damage into irreversible damage is played by cardiomyocyte membrane destruction caused by the so-called “lipid triad”. The latter comprises activation of lipid peroxidation, activation of phospholipases,(More)
The short-term adaptation of the heart cells to changing damands in controlled by the phosphorylation potential. By influencing protein synthesis, the same parameter also determines the long-term adaptation. Alterations in protein synthesis are not only of great significance for heart weight, but result in altered structural and enzymatic properties of(More)
The main parameters of contraction and relaxation of papillary muscle strips taken from the left ventricle of control and exercise-adapted rats were measured. The isotonic peak shortening velocity and contraction amplitude of thin strips under low loads in adapted animals were 1.5 times higher compared to the corresponding controls. In thick strips an even(More)
Under the action of severe emotional painful stress the high concentration of catecholamines leads to the activation of peroxide oxidation of lipids in myocardium. Lipid peroxides affect membranes, responsible for the transport of calcium. As a result local necrobiosis and disturbances of the contractile function of the heart are developed. This emotional(More)
Adaptation of rats to repcated short-term stress exposure prevents, to a considerable extent, contractural and arrhythmogenic effects of high concentrations of extracellular Ca2+ on isolated heart. Increased efficiency of SR Ca2+-pump functioning and a significant increase in Ca2+ pump resistance to autolysis are proved to play the main role in this effect.
Three isoenzymes of creatine phosphokinase (CPK) were detected in rat heart myocardium after electrophoretic separation of the enzyme in agarose gel: MM isozyme, MB isozyme and BB isozyme. The ratio of their activities was 60:30:5. Total activity of CPK per unit mass of myocardium was increased concomitant with transformation of its isoenzyme spectrum(More)
Adaptation of animals to short-term stress exposure (ASE) protected the heart against arrhythmias in acute ischemia and reperfusion and eliminated the decrease in threshold of fibrillation and arrhythmias in acute myocardial infarction and postinfarction cardiosclerosis. Cardioprotective effect of ASE was provided not only by the activation of GABAergic,(More)
Calculation of RNA synthesis rate in the rat myocardium during compensatory heart hyperfunction (CHH) was based on the study of the dynamics of RNA concentration and degradation. The parallel consideration of RNA synthesis rate and phosphorylation potential ([ADP]·[Pi]/[ATP]) showed that in the early stage of CHH, RNA synthesis rate increase follows(More)
Two fractions of mRNA poly A+ and poly A− mRNA have been found in rat heart muscle by the method of affinity chromatography. These fractions amount to 30 and 70% of the total RNA respectively. The relationship between poly A+ and poly A−mRNA in myocardium does not alter in heart hyperfunction and aging. The lifespan of mRNA reduces to 2–3 hours in the(More)
Effects of acute lethal blood loss on postresuscitation heart impairment has been studied. Experiments were performed in mongrel male rats anesthesized with sodium pentobarbital (25 mg/kg). Functional metabolic heart impairments have been evaluated in different terms after resuscitation by isolated perfused heart method (Fallen et al., J. Appl. Physiol, 22(More)
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