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The activation gate of ion channels controls the transmembrane flux of permeant ions. In voltage-gated K(+) channels, the aperture formed by the S6 bundle crossing can widen to open or narrow to close the ion permeation pathway, whereas the selectivity filter gates ion flux in cyclic-nucleotide gated (CNG) and Slo1 channels. Here we explore the structural(More)
Under normal physiological conditions, the open probability of Slo2.1 K(+) channels is low. Elevation of cytosolic [Na(+)] and [Cl(-)] caused by ischemia or rapid electrical pacing of cells increases the open probability of Slo2.1 channels and the resulting outward current can stabilize the resting state of cells. Initial characterization of heterologously(More)
'Manually Curated Database of Rice Proteins' (MCDRP) available at http://www.genomeindia.org/biocuration is a unique curated database based on published experimental data. Semantic integration of scientific data is essential to gain a higher level of understanding of biological systems. Since the majority of scientific data is available as published(More)
A large fraction of binary classification problems arising in web applications are of the type where the positive class is well defined and compact while the negative class comprises everything else in the distribution for which the classifier is developed; it is hard to represent and sample from such a broad negative class. Classifiers based only on(More)
Platelets are critical to hemostatic and immunological function, and are key players in cancer progression, metastasis, and cancer-related thrombosis. Platelets interact with immune cells to stimulate anti-tumor responses and can be activated by immune cells and tumor cells. Platelet activation can lead to complex interactions between platelets and tumor(More)
— Vehicular Ad hoc Networks (VANET) is the subclass of Mobile Ad Hoc Networks (MANETs). It is the most advanced technology that provides Intelligent Transportation System (ITS) in wireless communication among vehicles to vehicles and road side equipment (RSUs) to vehicles according to IEEE 802.11p standard. VANET provides broad range of safety and non(More)
The polarity of opinion is a crucial part of information and ignoring the asymmetry between them, can potentially result in an inaccurate estimation of the number of product adoptions and incorrect recommendations. We analyze the propagation patterns of the negative and positive opinions on two real world datasets, Flixster and Epinions, and observe that(More)